P-0263 - Factors affecting survival of patients who underwent surgical resection of pulmonary metastases from colorectal cancer
|Date||28 June 2014|
|Event||World GI 2014|
|Topics|| Colon Cancer
Surgery and/or Radiotherapy of Cancer
|Citation||Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165|
F. Lumachi1, S. Basso2, L. Foltran3, G. Lo Re4, G. Chiara2
Approximately 15-20% of patients with colorectal cancer will develop lung or liver metastases during follow-up. Unfortunately, the optimum treatment for patients with pulmonary metastases is controversial, and several prognostic factors have been suggested. The aim of this study was to analyze whether the site of primitive tumor affects survival of patients with lung metastases who underwent curative surgical resection.
A series of 32 consecutive patients with pulmonary metastases from colorectal cancer (N = 24) and noncolorectal cancer (N = 8), who underwent pulmonary resection was reviewed. There were 27 (84.3%) men (median age 63 years, range 39-74 years), and 5 (15.6%) women (median age 62 years, range 42-73 years). Only six (18.7%) patients had symptomatic pulmonary lesions. Twenty-one (65.6%) patients had a solitary metastatic tumor, whilst 11 (34.4%) had two or three lesions.
At final pathology the mean size of the tumor was 16.5 +/- 8.0 mm. No difference was noted in the survival rate according to the number and size of metastatic tumors (p = 0.43), although patients with solitary and smaller lesions had a better survival than those with multiple lesions. Nine patients died during follow-up. The overall survival was 26.5 +/- 2.6 months for patients with colorectal cancer vs. 25.2 +/- 13.8 months for patients with noncolorectal cancer (p = 0.32) as primitive tumor.
In this short-term study the pathological characteristics of the metastatic lesions, as well as the site of the primitive tumor, did not appear to be as strong prognostic determinants for survival. Thus, the primary tumor site should not be considered a major criterion in selected patients for surgical resection.