P-0018 - Evaluation of patient characteristics and 5-years survival rate in patients operated for gastric cancer in Bulgaria

Date 28 June 2014
Event World GI 2014
Session Poster Session
Topics Gastric Cancer
Cancer Aetiology, Epidemiology, Prevention
Presenter Kostadin Angelov
Citation Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165
Authors K. Angelov, G. Todorov, M. Vasileva, K. Grozdev, S. Toshev, T. Sedloev
  • Medical University of Sofia, Sofia/BG

Abstract

Introduction

The average 5-years survival rate from gastric cancer in Europe for the period from 1999 to 2007 is 25.1%. Bulgaria has the lowest 5 years survival rate from all European countries – 11.9%.

Methods

We performed a retrospective study of all patients operate from gastric cancer for 9 years period of time from January 2005 to December 2013. The patients were treated in Clinic of surgery of “Aleksandrovska” hospital – Sofia. We investigated the distribution according to age, sex, histological type and TNM classification as well as the 5 years survival rate.

Results

This study includes 155 patients - 99 men, and 56 women with mean age 62.22 years (from 27 to 85). The incidence rate was highest in the group over 65 years. The mean age at diagnosis for women was 60.42 years and for men – 63.24. Information about the TNM staging was available for 144 patients. The most of them – 57 had tumors penetrates subserosal connective tissue without invasion of visceral peritoneum or adjacent structures (T3). 45 patients had between 1 and 6 metastatic lymph nodes. 92 of the patients had no sigh of metastatic disease at the time of diagnosis. The follow up was possible for all patients in the trail. The 5 years survival rate was investigated for the patients treated between 2005 and 2008 - 69 patients. 43 of them were men and 26 were women. The mean age was 61.87 (from 27 to 81). 59 patients didn't have 5-years survival. Only one of them had tumor - T1, 7 patients had T2, 17 patients had tumors T3, 24 patients had T4 and in 10 patients T stage wasn't defined. 10 patients had 5-years survival, which is 14.49% of all. All of these patients are living by now. 6 were women and 4 men. The mean age was 62.30 (48-72). 3 patients had tumors penetrates serosa (visceral peritoneum) without invasion of adjacent structures (T3) 3 patients had tumors invading muscularis propria (T2), and 3 patients had tumors invading lamina propria, muscularis mucosae, or submucosa (T1). There were no patients in T4 stage.

Conclusion

The results of this study show the similar distribution of gastric cancer according to sex and age as in the rest of the world. Gastric cancer is almost twice more often in men with a peak incidence after 50 years. The 5-years survival of our patients is higher than average for our country but still lower comparing to all other European countries. For seven years Bulgaria has rise from 17th place of ASR mortality in 2005 to 9th place in the world in 2011. This shows the need of improving the treatment strategies for this disease.