Synergistic vs protective activity of cerium oxide nanoparticles (CNP) in gastrointestinal tumoral and non-tumoral cell cultures respectively when...

Date 28 June 2017
Event ESMO World Congress on Gastrointestinal Cancer 2017
Session ESMO World Congress on Gastrointestinal Cancer 2017
Topics Gastrointestinal Cancers
Basic Science
Presenter Jose Vazquez Villa
Citation Annals of Oncology (2017) 28 (suppl_3): iii13-iii136. 10.1093/annonc/mdx261
Authors J. Vazquez Villa, A. Garcia Fuente, D. Martinez Perez, R. Fernandez Fernandez, G.A. Francisco J, J.I. Martin Carbajo, P. Fonseca, J. Ferrer
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Abstract

CNP exerts a catalase activity that differs between tumour and normal cells.

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They have been reported to enhance the antitumor activity of doxorubicin, probably related to reactive oxygen species (ROS) generation, and oxidative damage after co-incubation. In contrast CNP do not cause damage and even protect human dermal fibroblast (Mol Cancer Ther. 2014; 13:1740). However, this activity is insufficiently studied in different cellular lines and with different cytotoxic agents.