89P - Abundance of Treg cells in oral cancer patients and effects of their inhibition on growth of cancer cells (89P)

Date 08 December 2017
Event ESMO Immuno-Oncology Congress 2017
Session Lunch & Poster Display session
Topics Bioethics, Legal, and Economic Issues
Presenter Sadhna Aggarwal
Citation Annals of Oncology (2017) 28 (suppl_11): xi6-xi29. 10.1093/annonc/mdx711
Authors S. Aggarwal, S.N. Das, S.C. Sharma
  • Biotechnology, ALL INDIA INSTITUTE OF MEDICAL SCIENCE, 110029 - Delhi/IN

Abstract

Background

Oral squamous cell carcinoma (OSCC) is one of the major cancers affecting Asian countries. The main causative factor has been the tobacco habit. It has been reported that immune dysfunction in these patients is one of the major factors for tumor growth and dissemination that affects disease-free survival of the patients.

Methods

We assessed the phenotypic and functional characteristics of Regulatory T (Treg) CD4+CD25+FoxP3+subsets in patients (n = 53) with OSCC and healthy individuals (n = 30) by multicoloured flow cytometry. Subsequently we investigated the effects their inhibition via TDG on growth of OSCC cell lines in vitro.

Results

An increased (p 

Conclusions

Hence, it seems reasonable to assume that modulation of functional dynamics of selective Treg subsets may be useful in enhancing anti-tumor immunity and developing immunotherapeutic strategies for patients with oral squamous cell carcinoma.

Clinical trial identification

Legal entity responsible for the study

Sadhna Aggarwal

Funding

None

Disclosure

All authors have declared no conflicts of interest.