309P - Overview on GTN in YGH (309P)

Date 18 November 2017
Event ESMO Asia 2017 Congress
Session Poster lunch
Topics Cancer in Pregnancy
Cancer in Special Situations
Gynaecologic Malignancies
Presenter SAN Myint
Citation Annals of Oncology (2017) 28 (suppl_10): x86-x93. 10.1093/annonc/mdx663
Authors S.Y. Myint, P. Phyu Theint, S.S. Win, Z. Thynn, H.H. Maw
  • Medical Oncology, University of Medicine I, 11131 - Yangon/MM

Abstract

Background

Gestational trophoblastic neoplasia (GTN) is a curable malignancy among female cancers and is quite common in our country. Occurrence is increasing and the disease course seems more aggressive. So we aimed to review our care and status of GTN in patients who attend to Yangon General Hospital (YGH).

Methods

This summary descriptive study was undertaken in the Medical Oncology Department of YGH, the main tertiary centre in Myanmar. Cases were collected from October 2015 to September 2016. Data analysis was done by age, risk score, βhCG level, sites of metastasis, surgeries received, types of regimes and numbers of cycles, response and outcomes up to June 2017

Results

Among the total of 58 patients the youngest was 17 and the oldest was 51, mean age was 33, βhCG level were above 100,000 in 33 (56.6%) and below in 25 (43.1%). Most common metastasis site was lung 13 (22.4%), brain 3(5.1%). Bladder invasions were seen in 4 (6.8%). 11 patients (18.9%) showed low risk score and 47 (81%) had high risk score. 52 patients (89%) had diagnosis by suction curettage and 6 patients (10.3%) had total hysterectomy due to uncontrolled bleeding. Single agent chemotherapy was given to 14 (24.1%) and EMA CO regime to 44 (75%), later change from single agent to EMA CO were 4 (6.8%) and from EMA CO to EMA CE were 5 (8.6%). Total cycles of chemotherapy for complete remission were more than 6 cycles for 20 (34.4%). 21 patients (36%) did not complete treatment and 4 patients (6.8%) expired during treatment due to severe late stage disease complications. Complete remission was seen in 33 (58%) with regular follow up. Grade 3 hematological toxicity (neutropenia) was seen in most of the cases but was manageable. Radiotherapy was given to the brain metastasis.

Conclusions

Since, our hospital is a tertiary centre serious cases were referred to us. Most of the patients showed complete remission except those who did not complete treatment, which may be due to socioeconomic problems. Strategies to develop resources, better clinical documentation and proper referral systems need to improve.

Clinical trial identification

Legal entity responsible for the study

University of Medicine 1

Funding

None

Disclosure

All authors have declared no conflicts of interest.