125P - Impact of the Time To Initiation of Chemoradiation on Outcome of Glioblastoma (125P)

Date 18 November 2017
Event ESMO Asia 2017 Congress
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Central Nervous System Malignancies
Surgery and/or Radiotherapy of Cancer
Presenter Abdullah Al Alhumiqani
Citation Annals of Oncology (2017) 28 (suppl_10): x35-x38. 10.1093/annonc/mdx657
Authors A. Al Alhumiqani1, A.K..A.K. Altwairgi1, B.M. Basulaiman1, A. Balbaid2
  • 1Comperhensive Cancer Center -medical Oncology, King Fahad Medical City, 11525 - Riyadh/SA
  • 2Comperhensive Cancer Center -radiation Oncology, King Fahad Medical City, 11525 - Riyadh/SA

Abstract

Background

Glioblastoma multiforme (GBM) is the most common, malignant primary brain tumor. Surgical resection followed by concurrent Chemoradiation (CCRT) and adjuvant chemotherapy is the standard treatment at this time. Unlike other tumors, the impact of the time to initiation of CCRT on outcome remains unclear. The aim of this analysis was to investigate the impact of time to initiation of CCRT on outcome in patients with GBM treated at King Fahad Medical City (KFMC), Saudi Arabia.

Methods

All adult patients treated with CCRT at KFMC from January 2008 until June 2016 were included. A data collection form was developed to collect patient demographics, pathology, radiotherapy and chemotherapy details, progression and survival outcomes. The interval to initiation of CCRT was determined from the time of surgical intervention. The impact of the time to initiation of CCRT on overall (OS) and progression-free (PFS) survival was evaluated by univariate Log-rank tests and multivariate Cox-regression analysis.

Results

In this analysis, 100 patients treated with CCRT were included. Median age was 49 (18-81). 72% of included patients were male, and 89% underwent resection. The majority of patients, 79% received adjuvant Temozolomide (TMZ) with a median of 4 cycles. The median of time to initiation of CCRT was 5.1 weeks (1.4 to 12.8) with 33% of patient were started on CCRT beyond six weeks of surgery. In univariate and multivariate analyses, time to initiation of CCRT have no significant impact on either PFS (univariate, p = 0.81, multivariate, p = 0.96) or OS (univariate, p = 0.44, multivariate, p = 0.43). On multivariate analysis, the better survival rate was seen in patients received adjuvant TMZ (P = 0.001) and worse survival rates were associated with ECOG >2 (P = 0.009), the presence of comorbidities (P = 0.04) and residual disease (P = 0.004).

Conclusions

In this single-center retrospective study, no significant impact of the time to initiation of CCRT was demonstrated on the outcome of GBM patients. Prospective studies are needed to define the optimal timing of CCRT after surgical resection in GBM.

Clinical trial identification

Legal entity responsible for the study

Ethical Committee- King Fahad Medical City -Riyadh -Saudi Arabia

Funding: None

Disclosure: All authors have declared no conflicts of interest.