275P - Can tumor size, ultrasonographic findings, and serum human chorionic gonadotropin (HCG) levels predict the likelihood of malignant testicular histo...

Date 18 November 2017
Event ESMO Asia 2017 Congress
Session Poster lunch
Topics Biomarkers
Germ Cell Tumours
Genitourinary Cancers
Imaging, Diagnosis and Staging
Pathology/Molecular Biology
Presenter Gang Song
Citation Annals of Oncology (2017) 28 (suppl_10): x81-x85. 10.1093/annonc/mdx661
Authors G. Song
  • Urology, Peking University First Hospital, 100034 - Beijing/CN

Abstract

Background

To predict the likelihood of malignant histology for testicular masses and decide more testis-sparing surgeries prior to surgery.

Methods

Three hundred twenty-five consecutive testicular mass patients who underwent radical orchiectomy or testicular preserving surgery (15/325) from January 1, 2001 to June 30, 2016 were enrolled in our study. We evaluated the predictive role of tumor diameter, cryptorchidism history, ultrasound findings, serum alpha fetoprotein (AFP) and human chorionic gonadotropin (HCG) levels to assess the likelihood of malignant testicular histology. A predictive nomogram was also generated to evaluate the quantitative probability.

Results

There were 78 (24.0%) benign and 247 (76.0%) malignant testicular tumor patients in our study cohort. Larger tumor diameter (per centimeter increased, hazard ratio [HR] =1.286, p = 0.040), lower ultrasound echo (HR = 3.428, p 

Conclusions

According to our data, the proportion of patients who underwent radical orchiectomy for benign tumors (24%) was much larger than generally believed (10%). Our results suggest that the diameter, ultrasonic echo, ultrasonic blood flow and serum HCG levels could predict the malignancy in testicular mass patients.

Clinical trial identification

Legal entity responsible for the study

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center of China, Beijing, China.

Funding

None

Disclosure

All authors have declared no conflicts of interest.