320O - B-cell Non-Hodgkin Lymphoma and Hepatitis C virus: Clinical Features and survival (320O)

Date 18 November 2017
Event ESMO Asia 2017 Congress
Session Haematological malignancies
Topics Lymphomas
Cancer in Special Situations
Haematologic Malignancies
Presenter Alshimaa Alhanafy
Citation Annals of Oncology (2017) 28 (suppl_10): x94-x99. 10.1093/annonc/mdx664
Authors A.M. Alhanafy1, N. Elabd2, E. Ahmedy3
  • 1Department Of Clinical Oncology And Nuclear Medicine, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 2Department Of Tropical Medicine, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG
  • 3Department Of Clinical Pathology, Menoufia University , Faculty of Medicine, 32511 - Shebin El Kom/EG

Abstract

Background

In Egypt, which has a high prevalence of HCV infection, a subset of B-cell non-Hodgkin lymphomas (B-NHL) was linked to HCV infection. HCV infection may affect liver functions causing bad tolerance to chemo-immunotherapy, suboptimal responses and poor outcomes.

Methods

This retrospective study included patients with B-NHL with known HCV infection status, by ELISA and/or RT-PCR, who presented to the Department of Clinical Oncology and Nuclear Medicine, Menoufia University between January 2012 and December 2013; all data were collected, tabulated and analyzed, patients with unknown HCV status at presentation and/or with incomplete paper file were excluded from this analysis.

Results

This study included 221 patients with B cell NHL, 121 (54.8%) patients were HCV negative and 100 (45.2%) patients were positive. The mean age 45.46±13.44 versus 57.19±10.91 in HCV negative and positive patients, respectively, and the difference was significant (p 

Conclusions

In Egypt, a high percentage of B cell lymphoma patients are HCV positive. HCV-positive lymphoma tend to have more advanced stage, more B symptoms, higher IPI score and shorter time to progression.

Clinical trial identification

Legal entity responsible for the study

Menoufia University

Funding

None

Disclosure

All authors have declared no conflicts of interest.