416P - Typical morphological features revealed unfavorable survival benefits in high-grade neuroendocrine carcinomas

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Neuroendocrine Cancers
Pathology/Molecular Biology
Presenter Hao-ran Zhai
Citation Annals of Oncology (2016) 27 (suppl_9): ix130-ix131. 10.1093/annonc/mdw590
Authors H. Zhai1, J. Zhang1, L. Yan2, C. Zhang1, J. Su1, S. Dong1, Q. Nie1, R. Liao1, B. Jiang1, X. Yang1, Y. Wu3, W. Zhong1
  • 1Guangdong Lung Cancer Institute, Guangdong General Hospital, 510080 - Guangzhou/CN
  • 2The Department Of Pathology, Guangdong General Hospital, 510080 - Guangzhou/CN
  • 3Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, 510080 - Guangzhou/CN



The 2015 WHO classification of lung cancer has proposed an revision about high-grade neuroendocrine carcinomas(HGNEC). Neuroendocrine(NE) markers are necessary for differentiations in cases lacing in typically morphological features, but their roles in survival benefits remain unclear.


A total of 700 consecutive patients diagnosed with pNET were re-diagnosed during 2008 to 2015 and 632 were HGNECs. NE markers, such as Syn(synaptophysin), CgA(chromogranin A) and CD56, were stained by immunohistochemistry(IHC) if morphological features were not enough for diagnoses.


Four were excluded due to clinical identification of transformation from adenocarcinomas to SCLC. Nine HGNECs were previously diagnosed with AC. TTF1 stained 77.4%(459/593) HGNEC patients, of which 50.6% in LCNEC, 80.9% in SCLC and 62.5% in poorly differentiated HGNEC(P 


The number of positive NE markers were necessary for precise diagnoses but not significant for survival benefits. Typical morphological features of NE tumor cells were unfavorable factors for OS. Further studies are imperative to identify its crucial role in HGNEC patients.

Clinical trial indentification

This is not a clinical trial.

Legal entity responsible for the study



The National Natural Science Foundation of China


All authors have declared no conflicts of interest.