61P - Tumor-infiltrating lymphocytes/macrophages and clinical outcome in breast cancer
|Date||17 December 2016|
|Event||ESMO Asia 2016 Congress|
|Topics|| Pathology/Molecular Biology
|Citation||Annals of Oncology (2016) 27 (suppl_9): ix9-ix18. 10.1093/annonc/mdw574|
Y. Kim, J. Kim
Breast cancer is composed of the malignant tumor cells and tumor microenvironment, which includes inflammatory cells. The inflammatory cells, known as lymphocytes and macrophages, regulate and release inflammatory mediators with pro-angiogenic or pro-metastatic effects in breast cancer. Tumor infiltrating lymphocytes(TILs) and tumor-associated macrophages(TAMs) are regarded to play a key role in progression and metastasis of various tumors. We evaluated their correlation with clinicopathologic parameters and prognosis in breast cancer.
A total of 73 patients with stage I to III breast cancer who underwent surgery at Uijeongbu St. Mary’s Hospital were included. The mRNA expression of CD163 and FoxP3 were investigated by quantitative reverse transcription polymerase chain reaction in fresh-frozen breast cancer tissues and adjacent non-cancerous breast tissues. Clinicopathologic parameters including tumor size, lymph node metastasis, stage, the expression status of hormonal (estrogen and/or progesterone) receptor, and human epidermal growth factor receptor-2 were analysed. Also, survival data were reviewed.
Tumor tissues had higher mRNA expression than normal tissues(p
Our results showed that larger tumor size, advanced stage, lymph node metastasis were associated with high TAMs and TILs infiltration. In addition, high FoxP3 expression was one of the independent prognostic factors for overall survival in breast cancer.
Clinical trial indentification
Legal entity responsible for the study
This study was approved by the Institutuinal review board of Uijeongbu St. Mary\'s hospital(UC16SIS0079)
All authors have declared no conflicts of interest.