373P - Synchronous or metachronous esophageal cancer is associated with a lower survival rate in patients with head and neck squamous cell carcinoma
|Date||17 December 2016|
|Event||ESMO Asia 2016 Congress|
|Topics|| Oesophageal Cancer
Cancer Aetiology, Epidemiology, Prevention
Head and Neck Cancers
|Presenter||Hee Man Kim|
|Citation||Annals of Oncology (2016) 27 (suppl_9): ix112-ix122. 10.1093/annonc/mdw587|
H.M. Kim1, J.H. Lee1, S.J. Baek2
It is well known that patients with head and neck squamous cell carcinoma (SCC) have a high incidence of synchronous or metachronsous esophageal SCC. This study attempted to investigate an effect of esophageal cancer on the survival of patients with head and neck cancer (HNC).
Of patients with HNC, those with pathologically-proven SCC were enrolled in Wonju Severance Christian Hospital, Wonju, Korea. All patients received esophagogastroduodenoscopy at the time of HNC diagnosis and at regular interval. Survival times were calculated by Kaplan-Meier analysis and compared by log rank test.
Between 2000 July and 2013 June, a total of 218 patients with HN SCC were analyzed with 202 men (92.7%) and a mean age of 64.3 ± 11.0. Esophageal SCC was diagnosed in 15 patients (6.5%) with a mean age of 61.7 ± 9.4 years and gastric neoplasm including tubular adenoma and adenocarcinoma was diagnosed in 13 patients (5.6%) with 66.2 ± 7.9 years, and both cancers were diagnosed in 1 patient (0.4%). The rate of synchronous and metachronous esophageal SCC was 6 (40%):9 (60%). The median follow-up time was 29.8 moths (0-149.4). The estimated survival times were 74.6 (95% CI: 65.3-83.9) of HNC without EC and 38.1 (95% CI 20.2-56.1) of HNC with EC (P = 0.042).rn
|Agern||61.7 ± 9.4rn||66.2 ± 7.9rn||69rn|
|Squamous cell carcinomarn||15 (100%)rn||0rn||1rn|
|Middlern||8 (53.3%)rn||7 (53.8%)rn||rn|
|Lowerrn||5 (33.3%)rn||5 (38.5%)rn||Srn|
Esophageal SCC had a negative effect on a survival of patients with head and neck SCC.
Clinical trial indentification
Legal entity responsible for the study
Hee Man Kim
Yonsei University Wonju College of Medicine
All authors have declared no conflicts of interest.