313P - Secretory cells expansion as a very early event in ovarian high-grade serous carcinoma

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Ovarian Cancer
Pathology/Molecular Biology
Presenter Alexandra Asaturova
Citation Annals of Oncology (2016) 27 (suppl_9): ix94-ix103. 10.1093/annonc/mdw585
Authors A. Asaturova1, L.V. Adamyan2, M.V. Sannikova3, N.M. Fayzullina1, G.N. Khabas3, L.S. Ezhova1
  • 1Pathology, Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" Ministry of Healthcare of the Russian Federation, 117997 - Moscow/RU
  • 2Gynecological Surgery, Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" Ministry of Healthcare of the Russian Federation, 117997 - Moscow/RU
  • 3Innovative Gynecological Oncology, Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology" Ministry of Healthcare of the Russian Federation, 117997 - Moscow/RU

Abstract

Background

Ovarian high-grade serous carcinoma (HGSC) is one of the most aggressive and widely spread gynecological tumors all over the world. We studied the incidence of secretory cell expansion (SCE) and secretory cells outgrowth (SCOUT) in the of the fallopian tube in patients with gynecological pathology, determined their immunophenotype and biological role in the early stages of ovarian of HGCS searching the early diagnostic test for HGSC.

Methods

287 patients with benign serous ovarian cystadenomas (n = 75), borderline serous ovarian tumors (n = 73), HGSC (n = 69) and extraovarian pathology (n = 70) were recruited, the fallopian tubes were investigated morphologically and immunohistochemically (p53, Ki-67, PAX2, bcl-2, beta-catenin, ALDH1) with semiquantative assessment (0 for negative, 1 – for weak, 2 – for moderate and 3 – for strong expression. Mann-Whitney and χ2 tests was used for statistics.

Results

Incidence of SCE (> 10 secretory cells in a row) and SCOUT (> 30 secretory cells in a row) increases with age in all groups. SCE were revealed 5.9-fold more frequent in patients with HGSC than in patients with extraovarian pathology (p 

Conclusions

We have shown that the SCE was an independent intraepithelial lesions. The frequency of SCE increase with age. The difference in frequency of SCE between patients with extraovarian pathology and HGSC was more significant than difference in frequency of SCOUT between these groups. Thus, SCE can be a more sensitive marker for the early stages of the pathogenesis of HGSC. Multiple molecular events occur in SCE and the therapeutic effect on the early stages of pathogenesis may have several points of application.

Clinical trial indentification

Legal entity responsible for the study

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation

Funding

Federal State Budget Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of the Russian Federation

Disclosure

All authors have declared no conflicts of interest.