98P - Seaweed extract and fucoidan on breast cancer cell proliferation

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Breast Cancer, Early Stage
Basic Science
Presenter seied hadi Chavoshi
Citation Annals of Oncology (2016) 27 (suppl_9): ix19-ix29. 10.1093/annonc/mdw575
Authors S.H. Chavoshi, M. Chavoshi
  • Internal Medicine, Shahid Ghazi Medical Center,Tabriz University of Medical Sciences, 5168668819 - Tabriz/IR

Abstract

Background

Breast cancer (BC) is the most common malignancy among women in different societies. Several studies on interactive effect of marine algae extracts and its active ingredient in fucoidan has been shown to control cell division in BC cells in vitro. In this article, we aimed to review the role seaweed extract and fucoidan on BC cells proliferation.

Methods

In this review, original and reviews studies published from 2006 to 2013 were summarized through PubMed, Google Scholar, Science Direct an Medline by searching for marine algae, Fucoidan and apoptosis as key words.

Results

Fucoidan, a sulfated polysaccharide compounds derived from brown algae and marineInvertebrates, are actively studied for some curative and preventive biological activities, such as anti-tumor activity in cancer. These agents have shown anticancer properties in breast, lung, and blood cancer cells. Seaweed extract and Fucoidan inhibited the proliferation of human cancer cells in normal human epidermal cells. It is effective in regulating the expression of C-MYC, cyclin D1, SURVIVIN genes and consequently the expression of these gene where down regulated. It seems that an intraperitoneal injection of Fucoidan, in animal models of BCreduce volume and weight of tumor. Studies show that after treatment by Fucoidan, cytochrom C releases from the mitochondria to the cytosol, and activates caspase 3 protein.Fucoidan might also induced apoptosis by reducing the cellular capacity through the reduction of cell glutathione capacity. Studies have showed that Fucoidan, inhibited cancer cells growth in G1phase of cell cycle, as well.

Conclusions

According to studies, marine algae extract and Fucoidan provide inhibitory effects on the growth and proliferation of breast cancer cells. Fucoidan could attribute in a prevention and also might considered as effective factor in chemothrepy.

Clinical trial indentification

Legal entity responsible for the study

Tabriz University of Medical Sciences

Funding

Tabriz University of Medical Sciences

Disclosure

All authors have declared no conflicts of interest.