82P - Risk factors for breast cancer: A case-control study among post-menopausal women in Pakistan

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Breast Cancer, Early Stage
Cancer Aetiology, Epidemiology, Prevention
Presenter Nauman Arif Jadoon
Citation Annals of Oncology (2016) 27 (suppl_9): ix19-ix29. 10.1093/annonc/mdw575
Authors N.A. Jadoon1, M. Hussain2, F.U. Sulehri2, A. Zafar3, A. Ijaz3
  • 1Medicine, Hull ROyal Infirmary, HU3 2JZ - Kingston upon Hull/GB
  • 2Medicine, Nishtar Medical College and Hospital (NMC) Clinical Oncology, 60000 - Multan/PK
  • 3Gastroenterology, Hull ROyal Infirmary, HU3 2JZ - Kingston upon Hull/GB

Abstract

Background

There is paucity of data on breast cancer risk factors in Asian population especially in the post menopausal group. This study was therefore carried out to determine the risk factors for breast cancer in this group. The objective of this study was to investigate the risk factors for female breast cancer in post-menopausal Pakistani population of southern Punjab.

Methods

A case control study involving 250 breast cancer patients and 500 controls that screened negative for breast cancer on mammography was carried out. Information about demographic characteristics and potential risk factors for breast cancer was gathered from both groups using standard questionnaire. Logistic regression analysis was employed to determine the association of various potential risk factors with breast cancer.

Results

In the multivariate logistic regression analysis, breast cancer risk was found to be significantly increased in women with age >40 years (OR = 1.84, 95% CI = 1.51-2.24), age at menarche ≤ 13 (OR = 1.45, 95% CI = 1.01-2.10), age at 1st live birth 4 (OR = 5.33, 95% CI = 1.96-14.53), living in rural areas (OR = 3.46, 95% CI = 2.29-5.84). There was no effect of contraceptive use on risk for breast cancer (OR = 0.93, 95% CI = 0.48-1.72) and family history of breast cancer (OR = 0.81, 95% CI = 0.22 – 1.02). In addition, no significant association was found between breast cancer risk and age of menopause, lactation, parity, breastfeeding and history of spontaneous or induced abortion.

Conclusions

The findings of this study suggest that age >40 years, age at menarche, age at 1st live birth and locality are significantly associated with increased breast cancer risk in post-menopausal Pakistani women in Southern Punjab.

Clinical trial indentification


Legal entity responsible for the study

Nishtar Medical College Hospital, Multan

Funding

Nishtar Medical College Hospital, Multan

Disclosure

All authors have declared no conflicts of interest.