427P - Quantitative severity of pulmonary emphysema as a prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Early Stage
Cancer in Special Situations
Surgery and/or Radiotherapy of Cancer
Presenter Seung Jun Lee
Citation Annals of Oncology (2016) 27 (suppl_9): ix134-ix135. 10.1093/annonc/mdw592
Authors S.J. Lee, Y.J. Cho, Y.Y. Jeong, J.D. Lee
  • Internal Mediceine, Gyeongsang National University Hospital and Gyeongsang National University School of Medicine, 660772 - Jinju/KR

Abstract

Background

Pulmonary emphysema is a major component of chronic obstructive pulmonary disease and lung cancer. However, the prognostic significance of quantitative emphysema severity in patients with lung cancer is unclear.

Methods

We quantified emphysema severity of whole lung and regional lobe using chest computed tomography-based automatic software in 45 patients (36 males and 9 females; mean age of 68.0) with surgically resected non-small cell lung cancer. Predicting factors for recurrence were investigated using Cox proportional hazards model. The recurrence-free survival was compared after dichotomization of patients according to the whole lung emphysema severity.

Results

The mean percent ratio of emphysema volume/whole lung volume was 1.21 ± 2.04. Regional lobar emphysema severity was highest in right middle lobe (1.93 ± 5.36), followed by right upper (1.35 ± 2.50), left upper (1.34 ± 2.12), left lower (1.05 ± 2.52), and right lower lobe (0.78 ± 2.28). Emphysema severity of whole lung (hazard ratio, 1.36; 95% confidence interval, 1.06 - 1.73) and stage III (hazard ratio, 6.17; 95% confidence interval, 1.52 - 25.0) were independent predictors of recurrence after adjustment for age, sex, smoking status, and forced expiratory volume in 1 second. The median recurrence-free survival of low emphysema and high emphysema group were 30.1 months and 22.0 months, respectively.

Conclusions

Although degree of emphysema was relatively low in this study population, quantitative emphysema severity of whole lung is associated with recurrence in patients with surgically resected non-small cell lung cancer.

Clinical trial indentification

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Legal entity responsible for the study

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Funding

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Disclosure

All authors have declared no conflicts of interest.