333O - Post-transplantation positron emission tomography scan is the main predictor of autologous stem cell transplantation outcome in diffuse large B cel...

Date 19 December 2016
Event ESMO Asia 2016 Congress
Session Haematological malignancies
Topics Lymphomas
Imaging, Diagnosis and Staging
Presenter Zhitao Ying
Citation Annals of Oncology (2016) 27 (suppl_9): ix104-ix111. 10.1093/annonc/mdw586
Authors Z. Ying1, X. Wang2, Y. Zhang2, Y. Song1, W. Zheng1, X. Wang1, Y. Xie1, N. Lin1, M. Tu1, C. Zhang1, L. Ping1, W. Liu1, L. Deng1, J. Zhu1
  • 1Lymphoma, Peking University Cancer Hospital-Beijing Cancer Hospital, 100142 - Beijing/CN
  • 2Nuclear Medicine, Peking University Cancer Hospital-Beijing Cancer Hospital, 100142 - Beijing/CN

Abstract

Background

The predictive value of 18F-FDG PET in patients with diffuse large B cell lymphoma (DLBCL) who are receiving high-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT) remains a matter of debate. This study evaluated the role of 18F-FDG PET scan in patients with DLBCL before and after ASCT.

Methods

Between Nov 2010 and Dec 2014, 65 patients with diffuse large B cell lymphoma were treated with HDC-ASCT at Peking University Cancer Hospital. 48 patients underwent PET imaging either before or after ASCT. Deauville criteria (5-point scale) was used to define negative (score 1,2 or 3) or positive (score 4 or 5) PET. The impact of pre- or post-ASCT PET on predicting prognosis were retrospectively analyzed.

Results

Median age was 43. The median follow-up time was 30.5 months. In a univariate analysis, negative pre- and post-ASCT PET was associated with better progression-free survival (PFS) and overall survival (OS) than positive pre- and post-ASCT PET (pre-ASCT PET, p = 0.007, p = 0.011; post-ASCT PET, p = 0.00, p = 0.00). Patients were also classified into four groups according to PET results before and after ASCT: those who were negative before and after (-/-; n = 26), positive before and negative after (+/-; n = 6), positive before and after (+/-; n = 8), negative before and positive after (-/+, n = 2). PFS and OS were significantly better for the -/- and +/- groups as compared with other groups (p = 0.00, p = 0.00). More importantly, there was no difference in terms of PFS and OS between the -/- group compared with +/- group. In the multivariate analysis, post-ASCT was identified as the only independent prognostic factor (PFS, p = 0.001; OS, p = 0.007).

Conclusions

Our study demonstrated post-ASCT PET is the main prognostic factor in patients with DLBCL.

Clinical trial indentification

Legal entity responsible for the study

Peking University Cancer Hospital IRB

Funding

Peking University Cancer Hospital

Disclosure

All authors have declared no conflicts of interest.