563P - Is triple negative breast cancer really bad? 10 year audit from a tertiary center

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Pathology/Molecular Biology
Presenter Prameela Chelakkot G
Citation Annals of Oncology (2016) 27 (suppl_9): ix181-ix183. 10.1093/annonc/mdw602
Authors P. Chelakkot G1, R. Ravind2, S. K3, W.M. Jose4
  • 1Radiation Oncology, Amrita Institute of Medical Sciences, 682041 - Kochi/IN
  • 2Radiation Oncology, HCG Bangalore Institute of Oncology Speciality Centre, Bangalore/IN
  • 3Radiation Oncology, Amrita Institute of Medical Sciences, Kochi/IN
  • 4Medical Oncology, Amrita Institute of Medical Sciences, Kochi/IN

Abstract

Background

Incidence of triple negative breast cancer (TNBC) is 15%-20%, and has relatively poor prognosis, attributed to absence of a definitive target molecule. Chemotherapy and adjuvant radiation remains the standard-of-care. Audit of all cases of TNBC treated at our tertiary cancer care centre was done with intent to analyze the pattern of failure.

Methods

Details of all TNBC patients, treated from January, 2004 to June, 2015 were retrieved from the electronic medical records and were analyzed.

Results

A total of 276 TNBC patients were treated in this 10 year period. Median age of presentation was 50 (range: 25-81). Median follow-up was 37.03 months. 96.4% of patients had infiltrating duct carcinoma. MRM was offered for 67.4% and BCS for 29.7%. 92% had axillary dissection. Upfront chemotherapy was offered for 18.8%, and adjuvant chemotherapy for 77.2%. 49.6% received adjuvant radiation. Fifty (18.1%) patients had recurrence; 4 local (1.4%), 3 regional (1.1%) and 40 distant (14.5%). Three patients had regional and distant failures. Among the 40 distant metastasis, 12 were brain, 8 skeletal, 4 hepatic, 2 pulmonary and 18 had multi-site. 144 (52.2%) patients were alive with no disease. 5-year OS was 88.03%. Stage was the only significant factor affecting OS. Stage I had 100% 5 year OS, stage II 95.5%, stage III 82.2% and stage IV 53.3% (p-

Conclusions

Contrary to western literature our TNBC patients had better survival: 3-year OS 74% vs. 90.08%. Failure in TNBC is generally systemic and is approximately 4 times more than loco-regional failures. Irrespective of nodal status T4 lesions fared poorly. Patients with BCS had less failures compared to MRM, probably due to early disease and addition of adjuvant radiation.

Clinical trial indentification

This was a retrospective analysis and an audit of all Triple Negative Breast cancer cases who had presented to the institue in the 10 year period. This was not a study protocol.

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.