389P - Hormonal receptor in nasopharyngeal cancer based on sex and histopathology in Abdul Wahab Sjahranie General Hospital

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Head and Neck Cancers
Pathology/Molecular Biology
Translational Research
Presenter Samuel Kelvin
Citation Annals of Oncology (2016) 27 (suppl_9): ix112-ix122. 10.1093/annonc/mdw587
Authors S. Kelvin1, E.N. Raharjo2, A. Darmadi Hariyanto1
  • 1Radiotherapy, RSUD Abdul Wahab syahranie, 75123 - Samarinda/ID
  • 2Pathology Anatomy, RSUD Abdul Wahab syahranie, 75123 - Samarinda/ID

Abstract

Background

World-wide, the head and neck cancers (HNC) form the sixth most common cancer. The prevalence of head and neck cancer In Indonesia, especially nasopharyngeal cancer (NPC) is 6.2 cases per 100000, with 13000 new NPC cases yearly. Hormonal Receptors [Estrogen Receptors (ER) and Progresterone Receptors (PR)] have an important role in gene expression involved in neoplastic process, e.g breast cancer, endometrium cancer, and prostate cancer. Previous studies found the presence of hormonal receptors expression in Immunohistochemistry (IHC) patients in HNC, but the role of hormonal receptors in the diagnostic and treatment for HNC has not become a standard protocol as is the case in breast cancer.

Methods

Sample were taken from NPC patients in Abdul Wahab Sjahranie general hospital from January 2014 until November 2015 who undergone biopsy in pathology anatomy department. 34 NPC patients who met the inclusion and exclusion criteria were examined by immunohistochemistry to assess the presence of ER and PR. This research used observational design study and the analysis of the data was done by using SPSS program version 17.

Results

Between 34 patients, there were 20 men and 14 women, mostly aged 41-60. Pathologic findings in 33 patients weRe NPC WHO type III. In IHC examination, 6 patients (17.6%) haD positive ER and 5 patients (14.7%) haD positive PR. There was no significant correlation between gender and hormonal receptor ER (95% CI, p = 0.672) and PR (95% CI, p = 1.000).

Conclusions

Hormonal receptors can be found in NPC for both genders (men and women) and there were no significant correlations between gender and hormonal receptor in this study.

Clinical trial indentification


Legal entity responsible for the study

Faculty of Medicine Mulawarman University

Funding

Abdul Wahab Sjahranie General Hospital

Disclosure

All authors have declared no conflicts of interest.