64O_PR - High mammographic breast density predicts locoregional recurrence after modified radical mastectomy for invasive breast cancer: A case-control study

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Breast cancer
Topics Breast Cancer, Early Stage
Imaging, Diagnosis and Staging
Surgery and/or Radiotherapy of Cancer
Presenter Yu-Sen Huang
Citation Annals of Oncology (2016) 27 (suppl_9): ix19-ix29. 10.1093/annonc/mdw575
Authors Y. Huang1, J.L. Chen2, S. Kuo3, Y. Chang1
  • 1Medical Imaging, National Taiwan University Hospital, 100 - Taipei/TW
  • 2Oncology, National Taiwan University Hospital, 100 - Taipei/TW
  • 3Department Of Oncology, National Taiwan University Hospital, 100 - Taipei/TW

Abstract

Background

We aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy.

Methods

This case-control study included 123 case-control pairs of women diagnosed with invasive breast cancer between 2004 and 2009 who had undergone modified radical mastectomy and had mammographic breast density measured before or at diagnosis. Women with known locoregional recurrence or distant metastasis were matched to women without recurrence by pathological disease stage, age, year of diagnosis, hormone receptor status, Her2 status, and adjuvant hormone or trastuzumab administration. Locoregional recurrence included recurrence in the ipsilateral breast, axillary or supraclavicular nodes, or contralateral breast. The median follow-up duration was 60.8 months for case patients and 61.3 months for control patients.

Results

Patients with heterogeneously dense (50–75% density) and extremely dense breasts (>75% density) had an increased risk of locoregional recurrence (hazard ratios, 3.9 and 8.4; 95% confidence intervals, 1.1–14.1 and 1.4–67.6; and p = 0.033 and 0.024, respectively). Multivariate analysis that included a lack of adjuvant radiotherapy and triple negative cancer revealed that dense breasts (>50% density) remained a significant factor for predicting locoregional recurrence risk (hazard ratio, 4.9; 95%; confidence interval, 1.4–17.3; and p = 0.013).

Conclusions

Our results demonstrate that dense breast tissue (>50% density) conferred a greater risk of locoregional recurrence after modified radical mastectomy in patients with invasive breast cancer. Additional prospective studies are necessary to validate these findings.

Clinical trial indentification

NCT02771665

Legal entity responsible for the study

National Taiwan University Hospital

Funding

Ministry of Science and Technology (MST, Taiwan, under contract of MST 105-2314-B-002-022-)

Disclosure

All authors have declared no conflicts of interest.