309PD - Features of cervical cancer in HIV-infected and uninfected women in association with human papilloma virus

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Gynaecological cancers
Topics Cervical Cancer
AIDS-Associated Malignancies
Presenter Murod Tashmetov
Citation Annals of Oncology (2016) 27 (suppl_9): ix94-ix103. 10.1093/annonc/mdw585
Authors M.N. Tashmetov
  • Oncology, Tashkent Medical Academy, 100169 - Tashkent/UZ

Abstract

Background

Annually 470000 new cases of cervical cancer are registered around the world and more than 270 000 of them are fatal. According to statistical data in the Republic of Uzbekistan, it is also observed the increased cervical cancer morbidity in women, mostly of reproductive age, with an average annual growth of 1.2%. In the analysis of the incidence of cervical cancer in the city of Tashkent in the period from 2010 to 2015 it was found that the number of newly detected patients in 2010 amounted to 121 cases, but by 2015 this igure had risen to 176 cases, besides which the frequency of advanced stages of malignancies had increased.

Methods

The study included 89 patients with cervical cancer associated with HPV, of them, the main group 49 (55.1%) patients were HIV-infected, and 40 (44.9%) patients were HIV-uninfected and made up the control group. Patients underwent treatment in clinic of Tashkent City Oncology Dispensary and in Republican Center of AIDS in the period from 2005-2015. Age of patients ranged from 25-70.

Results

Analysis of the results of examinations and treatment of 89 (100%) patients who were at different stages of cervical cancer according to data of colposcopy, cytology, viral load of HIV revealed that among 49 HIV-infected patients, in 25 (51%) cases was found T4, in 18 (37%) patients T2-T3, and the other 6 (12%) patients had T1 stage of disease.

Conclusions

The detection rate of late stages of cervical cancer (stage T4) among HIV-infected women compared with HIV-negative increased 5 times (51% and 10%, respectively). HIV-positive patients were mainly infected with both HPV 16 + 18 (80%). The tumor process is accompanied by the development of endogenous intoxication and decrease in immune strength of cancer patients, therefore the presence in a patient of HIV infection associated with HPV can lead to rapid progression of malignant neoplasms.

Clinical trial indentification

Legal entity responsible for the study

Tashkent Medical Academy

Funding

Tashkent Medical Academy

Disclosure

All authors have declared no conflicts of interest.