477P - Distinctive impact of whole-body metastases on the survival outcomes according to the histological subtypes in advanced non-small cell lung cancer

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Metastatic
Pathology/Molecular Biology
Presenter Dong Soo Lee
Citation Annals of Oncology (2016) 27 (suppl_9): ix139-ix156. 10.1093/annonc/mdw594
Authors D.S. Lee1, S.J. Kim2, Y.H. Ko3, J.W. Kim4, H.S. Jang5, Y.S. Kim5, J.H. Kang6
  • 1Department Of Radiation Oncology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, 11765 - Gyeonggi-do/KR
  • 2Division Of Pulmonology, Department Of Internal Medicine, Seoul St. Mary's Hospital, of the Catholic University, 137-701 - Seoul/KR
  • 3Department Of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, 11765 - Gyeonggi-do/KR
  • 4Division Of Pulmonology, Department Of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, 11765 - Gyeonggi-do/KR
  • 5Department Of Radiation Oncology, Seoul St. Mary's Hospital, of the Catholic University, 137-701 - Seoul/KR
  • 6Department Of Medical Oncology, Seoul St. Mary's Hospital, of the Catholic University, 137-701 - Seoul/KR

Abstract

Background

We launched this study to investigate the influence of whole-body metastases (WBM) on the survival outcomes according to the histological subtypes in stage IV non-small cell lung cancer (NSCLC).

Methods

Between June 2007 and June 2013, a total of 474 patients were included and analyzed. These patients were histologically proven as NSCLC and underwent systemic imaging work-up procedures. Synchronous WBM sites were categorized into 7 areas with the following: abdomen/pelvis; lung to lung or pulmonary lymphangitic spread; bone (skeletal system); pleural and/or pericardial metastasis; upper neck and/or axillary lymph nodes (LNs); other soft tissue; and brain. WBM scores were calculated from 1 to 7 by summation of each involved region. The patient, tumor, metastatic characteristics and the impact of WBM on overall survival (OS) were compared according to the histological subtypes.

Results

The enrolled study population comprised 82.9% (n = 393) non-squamous cell carcinoma (non-SQ) patients and 17.1% (n = 81) squamous cell carcinoma (SQ) patients. In the univariate survival analysis of SQ subgroup, gender (p = 0.009), age (p 

Conclusions

Although this study is limited due to small sample sizes, WBM significantly affected survival outcomes especially in the non-SQ populations. The indwelling relationship between WBM and OS should be further explored in the future studies.

Clinical trial indentification

None declared

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.