370P - Determination of bioimpedance in oral potentially malignant disorders

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Diagnostics
Head and Neck Cancers
Presenter Gargi Sarode
Citation Annals of Oncology (2016) 27 (suppl_9): ix112-ix122. 10.1093/annonc/mdw587
Authors G.S. Sarode, S.C. Sarode
  • Oral Pathology And Microbiology, Dr. D. Y. Patil Dental College and Hospital, Pimpri, 411018 - Pune/IN

Abstract

Background

Oral squamous cell carcinoma (OSCC) is an aggressive epithelial malignancy with around 270,000 new cases occurring annually. Diagnostic delay is a significant factor in disease progression. The time between diagnosis of oral potentially malignant disorder (OPMD) and malignant transformation is relatively short. Moreover, high-risk group individuals require repeated screening at regular intervals. Bioimpedance has emerged as a better screening tool over the current methods. Clinically and histopathologically relevant information about OSCC and OPMDs can be found in multi-frequency impedance spectra. At present, no studies using bioimpedance for the detection of OPMDs have been reported in the literature till date.

Methods

Four electrical properties for each OPMD were measured: impedance; phase angle; real part of impedance; and imaginary part of impedance using an impedance analyzer at six different frequencies with applied voltage of 200 mV.

Results

a. In leukoplakia, impedance values were seen to decrease from stage I to stage IV. Statistically significant differences in values of impedance were observed between all the stages of leukoplakia at 20Hz and 50kHz frequency. Impedance values declined as the histological grade progressed from no dysplasia to severe dysplasia. b. In erythroplakia, bioimpedance values declined as the histological grade progressed from no dysplasia to severe dysplasia. Statistically significant differences were also observed between all the grades of dysplasia at frequencies of 20Hz and 50kHz. c. In OSMF, impedance values declined as the histological grade progressed from mild to severe dysplasia. Statistically significant differences in values of impedance were also observed between all the grades at 20Hz and 50Hz. d. A statistical significant difference amongst all the parameters of different study groups was found at almost all the frequencies.

Conclusions

Bioimpedance can be developed as a routine diagnostic decision support tool that can assist the classical visual screening in screening programs, in primary care centers or in developing countries where the organizational structure and economical factors limit national screening programs.

Clinical trial indentification

Not applicable

Legal entity responsible for the study

N/A

Funding

The study was carried out in Dr. D. Y. Patil Dental College and Hospital

Disclosure

All authors have declared no conflicts of interest.