370P - Determination of bioimpedance in oral potentially malignant disorders
|Date||17 December 2016|
|Event||ESMO Asia 2016 Congress|
Head and Neck Cancers
|Citation||Annals of Oncology (2016) 27 (suppl_9): ix112-ix122. 10.1093/annonc/mdw587|
G.S. Sarode, S.C. Sarode
Oral squamous cell carcinoma (OSCC) is an aggressive epithelial malignancy with around 270,000 new cases occurring annually. Diagnostic delay is a significant factor in disease progression. The time between diagnosis of oral potentially malignant disorder (OPMD) and malignant transformation is relatively short. Moreover, high-risk group individuals require repeated screening at regular intervals. Bioimpedance has emerged as a better screening tool over the current methods. Clinically and histopathologically relevant information about OSCC and OPMDs can be found in multi-frequency impedance spectra. At present, no studies using bioimpedance for the detection of OPMDs have been reported in the literature till date.
Four electrical properties for each OPMD were measured: impedance; phase angle; real part of impedance; and imaginary part of impedance using an impedance analyzer at six different frequencies with applied voltage of 200 mV.
a. In leukoplakia, impedance values were seen to decrease from stage I to stage IV. Statistically significant differences in values of impedance were observed between all the stages of leukoplakia at 20Hz and 50kHz frequency. Impedance values declined as the histological grade progressed from no dysplasia to severe dysplasia. b. In erythroplakia, bioimpedance values declined as the histological grade progressed from no dysplasia to severe dysplasia. Statistically significant differences were also observed between all the grades of dysplasia at frequencies of 20Hz and 50kHz. c. In OSMF, impedance values declined as the histological grade progressed from mild to severe dysplasia. Statistically significant differences in values of impedance were also observed between all the grades at 20Hz and 50Hz. d. A statistical significant difference amongst all the parameters of different study groups was found at almost all the frequencies.
Bioimpedance can be developed as a routine diagnostic decision support tool that can assist the classical visual screening in screening programs, in primary care centers or in developing countries where the organizational structure and economical factors limit national screening programs.
Clinical trial indentification
Legal entity responsible for the study
The study was carried out in Dr. D. Y. Patil Dental College and Hospital
All authors have declared no conflicts of interest.