30P - Correlation between Ki-67 expression and clinic-pathological features of soft tissue sarcomas in the extremities

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Soft Tissue Sarcomas
Translational Research
Presenter Mohamed Kelany
Citation Annals of Oncology (2016) 27 (suppl_9): ix9-ix18. 10.1093/annonc/mdw574
Authors S. Abdelwahab, E. Saleh, A. Gaballa, M. Kelany, F. Sayed
  • Clinical Oncology, Ain Shams University Faculty of Medicine, 11511 - Cairo/EG

Abstract

Background

Soft tissue sarcomas (STSs) are a rare heterogeneous disease, Ki-67 is a nuclear protein highly expressed in the proliferative state of somatic cycle. We studied the prognostic value of Ki-67 expression and its primary tumor characteristics in adult patients with extremity STSs.

Methods

We retrospectively collected the clinical data of 40 patients with extremity STSs treated at Ain Shams university hospital from January 2010 to December 2012 and we correlated between Ki-67 expression by immunohistochemistry and the clinico-pathological data. We used a cutoff value of 20% for Ki-67 in tumor cells. The differences among variables were calculated by chi-quare test.

Results

High Ki-67 expression (>20%) was found in 20% of cases (8/40). High Ki-67 was significantly correlated with age > 50 years old (p 

Conclusions

In our study we found that high expression of Ki-67 protein >/20% in extremity STSs, is frequently associated with poor prognosis, including the occurrence of distant metastases.

Clinical trial indentification

the trial approved by Ain Shams University Faculty of medicine Research Ethics Committee on 25 November 2014 with numder= FMASU 3080/2014

Legal entity responsible for the study

Mohamed Kelany

Funding

Our own funding

Disclosure

All authors have declared no conflicts of interest.