30P - Correlation between Ki-67 expression and clinic-pathological features of soft tissue sarcomas in the extremities
| Date | 17 December 2016 |
| Event | ESMO Asia 2016 Congress |
| Session | Poster lunch |
| Topics | Soft Tissue Sarcomas Translational Research |
| Presenter | Mohamed Kelany |
| Citation | Annals of Oncology (2016) 27 (suppl_9): ix9-ix18. 10.1093/annonc/mdw574 |
| Authors |
S. Abdelwahab, E. Saleh, A. Gaballa, M. Kelany, F. Sayed
|
Abstract
Background
Soft tissue sarcomas (STSs) are a rare heterogeneous disease, Ki-67 is a nuclear protein highly expressed in the proliferative state of somatic cycle. We studied the prognostic value of Ki-67 expression and its primary tumor characteristics in adult patients with extremity STSs.
Methods
We retrospectively collected the clinical data of 40 patients with extremity STSs treated at Ain Shams university hospital from January 2010 to December 2012 and we correlated between Ki-67 expression by immunohistochemistry and the clinico-pathological data. We used a cutoff value of 20% for Ki-67 in tumor cells. The differences among variables were calculated by chi-quare test.
Results
High Ki-67 expression (>20%) was found in 20% of cases (8/40). High Ki-67 was significantly correlated with age > 50 years old (p
Conclusions
In our study we found that high expression of Ki-67 protein >/20% in extremity STSs, is frequently associated with poor prognosis, including the occurrence of distant metastases.
Clinical trial indentification
the trial approved by Ain Shams University Faculty of medicine Research Ethics Committee on 25 November 2014 with numder= FMASU 3080/2014
Legal entity responsible for the study
Mohamed Kelany
Funding
Our own funding
Disclosure
All authors have declared no conflicts of interest.