426P - Combined radiologic imaging modalities for prognosis of clinical IA adenocarcinomas

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Early Stage
Imaging, Diagnosis and Staging
Presenter Hiroaki Kuroda
Citation Annals of Oncology (2016) 27 (suppl_9): ix134-ix135. 10.1093/annonc/mdw592
Authors H. Kuroda1, H. Tanaka2, T. Mizumo1, N. Sakakura1, T. Yoshida3, Y. Yatabe4, H. Iwata2, Y. Sakao1
  • 1Thoracic Surgery, Aichi Cancer Center Hospital, 464-8681 - Nagoya/JP
  • 2Radiology, East Nagoya Radiological Diagnosis foundation, 464-0044 - Nagoya/JP
  • 3Thoracic Oncology, Aichi Cancer Center Hospital, 464-8681 - Nagoya/JP
  • 4Pathology And Molecular Diagnostics, Aichi Cancer Center Hospital, 464-8681 - Nagoya/JP

Abstract

Background

We previously proposed measuring tumor size using mediastinal window setting on high-resolution computed tomography (CT) as a simple and useful modality for preoperative prognostication of small adenocarcinoma. Here, the importance of tumor volume and positron emission tomography (PET) for preoperative prognostication of clinical stage IA (cIA) adenocarcinoma for anatomical pulmonary resection was studied.

Methods

We retrospectively evaluated total 326 patients who underwent pulmonary resection of cIA adenocarcinoma between July 2008 and August 2015. Reconstructed three-dimensional (3D) images from 1–1.5 mm-slice multi-detector row CT were evaluated for tumor total volume (TTV), consolidation volume (CV) on lung window setting, and mediastinal volume (MV) on MWS. The values examined by PET were total lesion glycolysis, maximum standardized uptake (SUV max), and mean SUV. Patient age, gender, preoperative CEA levels, and clinical staging were examined. Pathologic status was evaluated according to tumor size (PS), invasive size (IS), lymphatic and vascular vessels, pleural invasion, and TNM staging.

Results

Pathologic lymph node positivity, and IS were equivalent or superior to 3D imaging factors, preoperative patient variables, and PS, respectively. We used mean/MV to evaluate tumor quality and quantity, because only MV and CV were equivalent to IS. AUCs for mean/MV were 0.80, 0.82, and 0.81 and were ≥IS. Mean/MV was associated with lymph node metastasis, tumor invasiveness, histologic grade, and two-dimensional mediastinal diameter on MDCT. Among the various histologic subtypes, solid-predominant tumors had the highest mean/MV; the number of genomic triple-negative adenocarcinoma was significantly higher than adenocarcinoma harboring an exclusive gene of EGFR, KRAS, or ALK. Moreover, higher mean/MV significantly contributed to unfavorable disease-free survival in cIA adenocarcinomas.

Conclusions

The mean/MV value determination on 3D-reconstructed CT images was a simple and useful preoperative modality for predicting invasiveness, lymph node metastasis, and stage migration in cIA adenocarcinomas; higher values correlated with poorer prognosis and reflected tumor aggressiveness and extent of invasion.

Clinical trial indentification

Legal entity responsible for the study

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Funding

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Disclosure

All authors have declared no conflicts of interest.