111P - BMI effect prognostic features of breast cancer treatments

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Breast Cancer, Locally Advanced
Cancer Aetiology, Epidemiology, Prevention
Presenter Mohammad Hojouj
Citation Annals of Oncology (2016) 27 (suppl_9): ix30-ix34. 10.1093/annonc/mdw576
Authors M.I. Hojouj, I. Bondarenko
  • Oncology And Medical Radiology, Dnepropetrovsk State Medical Academy, 49102 - Dnepropetrovsk/UA

Abstract

Background

The (BMI) on the prognosis of metastatic breast cancer (MBC) has not been explored so far. Aim of this retrospective study is to evaluate the relation between patients’ Breast cancer (BC) to BMI and the prognosis of treatment.

Methods

The study included 143 patients with MBC between the ages of 30 and 76 (57,6 ± 1) yrs of age who were treated according to our clinic from 2006-2014. The main condition for selection was the treatment of MBC at the time of analysis. All patients were evaluated according to the following data: stage of the disease, age and BMI at the time of diagnosis, the size, histological type and degree of differentiation of the tumor and the presence of regional lymph nodes (RLN) metastases.Tumor size was evaluated after measuring its maximal diameter and distributed in accordance with the International TNM-classification . The absence of menstruation in patients over 1 year up to the moment of diagnosis was regarded as menopause. T. BMI is calculated by the formula:I = m h2, where m - body weight (kg) h -those with a BMI

Results

1. In this retrospective study, among 108 patients with breast cancer, 44% were identified with excess body weight, and 31% - of various obesity degree. 25% Patients with normal BMI. 2. Patients with a BMI 30 kg/m2, 11% more often associated with metastatic RLN, which is anindirect sign of a higher metastatic potentials. 4. Patients with normal BMI had significantly longer overall survival (OS) and disease-free survival (DFS) than patients with intermediate or obese BMI in pairwise comparisons adjusted for other factors, But this fact is preliminary and requires further study.

Conclusions

This retrospective investigation our patient I–VI demonstrates that BMI is an independent prognostic factor in patients with BC. We have supporting evidence that obese BMI represents a poor risk feature for outcome, especially in pre-/perimenopausal patients.

Clinical trial indentification

October 2015, UAE

Legal entity responsible for the study

Hojouj

Funding

Hojouj

Disclosure

All authors have declared no conflicts of interest.