347P - Association between allergic conditions and risk of non- Hodgkin lymphoma and Hodgkin lymphoma: A systematic review and meta-analysis

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Lymphomas
Cancer in Special Situations
Presenter Jia Yang
Citation Annals of Oncology (2016) 27 (suppl_9): ix104-ix111. 10.1093/annonc/mdw586
Authors J. Yang1, H. Xu1, P. Li2, X. Liang1, Y. Jia1
  • 1Department Of Radiotherapy, Zhejiang Provincial People’s Hospital, 310000 - Hangzhou/CN
  • 2Department Of Gastroenterology, 2nd Affiliated Hospital of Zhejiang University University School of Medicine, 310000 - Hangzhou/CN

Abstract

Background

We aimed to systematically evaluate the association between allergic conditions and risk of hodgkin lymphoma (HL) and non-hodgkin lymphoma (NHL).

Methods

Systematic literature searches in Pubmed and Embase was conducted up to October, 2015 to identify eligible studies. Either a fixed- or a random-effects model was adopted to estimate overall odds ratios (ORs) according to heterogeneity across studies.

Results

A total of 24 case-control studies with 35725 NHL cases and 13 cohort studies comprising 4452 NHL cases were included in the pooled analysis of NHL risk. An inverse association was observed between history of any allergic condition and NHL risk in case-control studies (OR = 0.83, 95% CI 0.76-0.91), while the reduction of NHL risk was not suggested in cohort studies (OR = 1.18, 95% CI 0.98-1.42). Stratifying by type of allergic conditions, significant association with NHL risk was found for asthma, hay fever, food allergy, allergic rhinitis and hives. In the pooled analysis of HL risk, 12 studies (2 were cohort studies) with 2750 HL cases were included. The pooled OR was 0.96 (95% CI 0.84-1.09) for case-control studies and 1.46 (95% CI 0.63-3.38) for cohort studies. For specific allergic condition, we observed a reducing HL risk in individuals with hay fever and food allergy.

Conclusions

Several specific allergic conditions, including asthma, hay fever, food allergy and allergic rhinitis were associated with reduced NHL risk, while hay fever and food allergy was inversely associated with HL risk. History of any allergic condition was not significantly associated with NHL or HL risk.

Clinical trial indentification

none

Legal entity responsible for the study

Jia Yang

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.