422P - A study on the correlation between body composition and durability of chemotherapy; A prospective cohort study

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Diagnostics
Presenter Jun Ho Ji
Citation Annals of Oncology (2016) 27 (suppl_9): ix132-ix133. 10.1093/annonc/mdw591
Authors J.H. Ji1, S.M. Kim2, S. Kim1, A. Seo3
  • 1Hemato-oncology, Samsung Changwon Hospital Sung Kyun Kwan University, 51353 - Changwon/KR
  • 2Internal Medicine, Samsung Changwon Hospital Sung Kyun Kwan University, 51353 - Changwon/KR
  • 3Health Promotion Center, Samsung Changwon Hospital Sung Kyun Kwan University, 51353 - Changwon/KR

Abstract

Background

Relative dose intensity (RDI) in anti-cancer chemotherapy represents an affecting factor on cancer survival. Body composition is the basic information of body and the test can be easily evaluated. The aim of this study was to investigate the relevance between RDI and body composition.

Methods

We conducted a prospective cohort study of 51 patients (31 of breast cancer, 20 of colon cancer) who were candidates for of adjuvant chemotherapy between May 2015 and July 2016 at a single institute. All of them gave informed consent and body composition testing was performed before initiating of adjuvant chemotherapy. The body composition was measured using bioelectrical impedance analysis with an InBody720 (Biospace, Tokyo, Japan). The variables in body composition included body mass index (BMI), body fat percentage, abdominal fat percentage, body fat mass, body water mass, total muscle mass, body weight (BW), skeletal muscle mass, skeletal muscle mass/BW, total muscle mass/BW and body fat mass/BW. The correlations of RDI and variables in body composition were determined using Pearson correlation coefficient analysis.

Results

In breast cancer, RDI had a significant correlation with BMI(r of 0.373, p = 0.039), skeletal muscle mass/BW (r of 0.582, p = 0.001), total muscle mass/BW (r of 0.526, p = 0.002), body fat mass/BW (r of -0.558, p 

Conclusions

High total muscle mass/BW and low body fat mass/BW were positively correlated with RDI in breast cancer and colon cancer with adjuvant setting. The body composition may be a potential parameter to predict prognosis in cancer chemotherapy.

Clinical trial indentification

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.