472P - Predictive and prognostic value of de novo MET expression in patients with advanced non-small cell lung cancer

Date 20 December 2015
Event ESMO Asia 2015 Congress
Session Poster presentation 2
Topics Non-Small-Cell Lung Cancer, Metastatic
Translational Research
Presenter Anna Li
Citation Annals of Oncology (2015) 26 (suppl_9): 125-147. 10.1093/annonc/mdv532
Authors A. Li1, Y.F. Niu1, J.J. Yang1, C.X. Zhang1, Q. Zhou2, J. Su1, Z. Xie2, N. Lou2, Z. Wen-Zhao3, H. Tu2, N. Zhao2, Y. Wu4
  • 1Division 1 Of Lung, Guangdong General Hospital, 510080 - Guangzhou/CN
  • 2Department Of Pulmonary Oncology, Guangdong General Hospital, Guangdong lung cancer institute, 510080 - Guangzhou/CN
  • 3Surgical Oncology, Guangdong General Hospital, 510080 - Guangzhou/CN
  • 4Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, 510080 - Guangzhou/CN

Abstract

Aim/Background

Cellular-mesenchymal-epithelial transition (MET) protein has recently been identified as a novel target that shows promise for the treatment of non-small-cell lung cancer (NSCLC). However, the relationship between de novo MET expression and patient outcomes remains unclear.

Methods

We reviewed the data of patients who had been diagnosed with NSCLC between December 2013 and October 2014. All the patients were evaluated for MET expression status. MET-positive was defined as having an H-score ≥60 by immunohistochemistry analysis. MET expression was analyzed in 158 patients who were negative for the common driver genes, including EGFR, ALK, KRAS and ROS1. A chi-squared test was used to assess the clinicopathological parameters. Multivariate analyses were performed using the Cox proportional hazards model.

Results

MET data were available for analysis in 158 advanced NSCLC patients. Of these, based on the MET H-score criteria, the IHC-positive rate was 48.1% (76/158). There were more patients with adenocarcinoma in the MET-positive group compared with the MET-negative group (P = 0.01). Nine patients with lymphoepithelioma-like carcinoma had no MET expression. There was no significant difference in overall survival (OS) between MET-positive and -negative patients. There was also no significant difference in the efficacy (Z = −0.44, P = 0.66) or progression free survival (PFS) of first-line chemotherapy between the MET-positive and -negative patients (mPFS 6.8 months [95% CI: 5.4-8.2] vs. 5.9 months [5.5-6.3], P =0.92).

Conclusions

Our data showed that de novo MET expression was not rare. It was not a predictive or prognostic factor for stage IV NSCLC patients, but this should be confirmed in larger population cohort.

Clinical trial identification

Disclosure

All authors have declared no conflicts of interest.