324P - Aloe vera: an ancient herb for radiation induced xerostomia and oral fibrosis

Date 20 December 2015
Event ESMO Asia 2015 Congress
Session Poster presentation 2
Topics Complications of Treatment
Surgery and/or Radiotherapy of Cancer
Presenter Jitendra Acharya
Citation Annals of Oncology (2015) 26 (suppl_9): 93-102. 10.1093/annonc/mdv527
Authors J.K. Acharya1, D..R. Garg1, R. Mathur1, S.L. Jakhar2, N.L. Mahawar3, R. Mathur4, A. Kwatra5, R.K. Mathur6, R.N. Purohit1
  • 1Dentistry, Sardar Patel Medical College and associated Prince Bijaysingh Memorial Hospital, 334001 - Bikaner/IN
  • 2Radiotherapy, Acharya Tulsi Cancer Treatment & Research Institut, 334001 - Bikaner/IN
  • 3Transfusion Medicine, Sardar Patel Medical College and associated Prince Bijaysingh Memorial Hospital, 334001 - Bikaner/IN
  • 4Radiodiagnosis, JLN MEdical College, 305001 - Ajmere/IN
  • 5Epidemiology, Sardar Patel Medical College and associated Prince Bijaysingh Memorial Hospital, 334001 - Bikaner/IN
  • 6Dentistry, Anchal bai dispensory, 334001 - Bikaner/IN

Abstract

Aim/Background

The oral cavity is highly susceptible to direct and indirect toxic effects of ionizing radiation in cancer patients. Development of new treatment modalities to prevent cancer therapy–induced complications, especially xerostomia and oral fibrosis. As has been noted, it is essential that a multidisciplinary approach be used for oral management of the cancer patient before, during, and after cancer treatment. Oral complications from radiation to the head and neck can compromise patients' health and quality of life. Recently, herbal medicine have been used to treat radiation induced xerostomia and oral fibrosis. Here we conducted a double-blind, prospective, randomized trial, we determined whether oral aloe vera gel can reduce radiation-induced xerostomia and oral fibrosis in head-and-neck cancer patients.

Methods

This study was started in Department of Dentistry with collaboration of Department of Radiotherapy in S.P.M.C., Bikaner, Rajasthan. A total of 150 subjects they were divided randomly into the following experimental groups: 1) Irradiated control group 2) aloe-vera experimental group. Unstimulated saliva samples were collected at the base line and 4 weeks after the usage of the 5 mg aloe vera gel. They were analyzed subjective symptoms as intra-oral dryness, eating ability and oral discomfort were graded by visual analogue scale.

Results

Data analysis study groups that had been given aloe vera, by ANOVA showed that there was a statistically significant difference (P < 0.05) in salivary flow, eating ability and oral discomfort as graded by visual analogue scale.

Conclusions

Within the limitations of this study aloe vera is effective as a radioprotective or antioxidant agent for preservation of glandular tissue and reduce fibrosis, as it helped to maintain salivary function and oral comfort.

Clinical trial identification

The sudy was done on march 2015 to july 2015.

Disclosure

All authors have declared no conflicts of interest.