608P - Variations in clinicopathological features, treatment patterns, and outcomes of young adults with colorectal cancer in the United States and Egypt

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Cancer in Young Adults
Colon Cancer
Rectal Cancer
Cancer in Special Situations
Gastrointestinal Cancers
Presenter Arielle Heeke
Citation Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393
Authors A. Heeke1, N. Rashad2, H.M. Khaled3, N. Ali Eldin4, G.A. Motaal2, H. Wang5, B. Weinberg1, M. Salem6
  • 1Hematology/oncology, Lombardi Comprehensive Cancer Center Georgetown University, 20007 - Washington/US
  • 2Medical Oncology, Maadi Armed Forces Hospital, 11728 - Cairo/EG
  • 3Medical Oncology, National Cancer Institute, 11796 - Cairo/EG
  • 4Biostatistics And Cancer Epidemiology, National Cancer Institute, 11796 - Cairo/EG
  • 5Biostatistics And Bioinformatics, Lombardi Comprehensive Cancer Center Georgetown University, 20007 - Washington/US
  • 6Hematology/oncology, Lombardi Comprehensive Cancer Center Georgetown University, 20007-2197 - Washington/US

Abstract

Background

A recent American Cancer Society study showed that the rate of colorectal cancer (CRC) in young American adults is rising. There are limited data on young Arabian adults with CRC. Herein we explore differences between American and Egyptian young adults with CRC.

Methods

A retrospective review of young (≤46 years old) patients (pts) with CRC in the United States (US-pts) and Egypt (EGY-pts) was undertaken. T and Fisher’s exact tests were used for comparative analyses. Kaplan-Meier methodology estimated survival.

Results

In total, 504 pts with CRC were studied, incorporating 62 US-pts (median age 38 yrs, range 20-46) and 442 EGY-pts (35 yrs, 15-46). US-pts were more commonly female (66% vs 41%, p 

Conclusions

Significant differences were observed among young US-pts and EGY-pts with CRC, particularly primary tumor location, patterns of metastasis, and treatment used. Further evaluation of the environmental and ethnic impact on disease biology and treatment outcomes is warranted.

Clinical trial identification

N/A

Legal entity responsible for the study

Georgetown University IRB

Funding

None

Disclosure

All authors have declared no conflicts of interest.