949P - Tumor microenvironment in high serous ovary cancer: characterization of the infiltration pattern and analysis of its prognostic value

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Ovarian Cancer
Gynaecologic Malignancies
Presenter Franklin Herrera Cañizares
Citation Annals of Oncology (2017) 28 (suppl_5): v330-v354. 10.1093/annonc/mdx372
Authors F. Herrera Cañizares1, A. Chipirliu2, C. Caballero3, A. HERREROS POMARES4, S. Calabuig Fariñas5, L. Valdivieso6, M. Mosqueda7, J. Marí Alexandre8, E. Jantus9, J. Gilabert10, C. Camps Herrero11
  • 1Laboratorio De Oncología Molecular, Fundación de Investigación Hospital General Universitario de Valencia. Fundación Carolina-BBVA, 46014 - Valencia/ES
  • 2Servicio De Ginecologia, Hospital General Universitario Valencia, 46014 - VALENCIA/ES
  • 3Servicio De Oncología Médica, Hospital General Universitario Valencia, 46014 - VALENCIA/ES
  • 4Laboratorio De Oncología Molecular, Fundación de Investigación Hospital General Universitario de Valencia, 46014 - Valencia/ES
  • 5Laboratorio De Oncología Molecular, Fundación Para La Investigación, Hospital General Universitario De Valencia-ciberonc;, Departamento de Patología, Universitat de València., 46020 - Valencia/ES
  • 6Anatomía Patologica, Hospital General Universitario Valencia, 46018 - Valencia/ES
  • 7Laboratorio De Oncología Molecular, Fundación para la Investigación, Hospital General Universitario de Valencia, 46020 - Valencia/ES
  • 8Hospital Universitario Y Politécnica La Fe De Valencia, IIS La Fe, Valencia, 46017 - Valencia/ES
  • 9Laboratorio De Oncología Molecular, Fundación Para La Investigación, Hospital General Universitario De Valencia-ciberonc;, Departamento de Biotecnología, Universidad Politécnica de Valencia, 46014 - Valencia/ES
  • 10Servicio De Ginecologia, Hospital General Universitario Valencia, 46014 - València/ES
  • 11Laboratorio De Oncología Molecular, Fundación Para La Investigación, Hospital General Universitario De Valencia. Ciberonc, Servicio de Oncología Médica, Hospital Hospital General Universitario de Valencia; Departamento de Medicina, Universidad de Valencia, 46018 - Valencia/ES

Abstract

Background

Lymphocytic infiltration areas (immunoreactive) are frequently found in ovarian cancer, which is associated with a better prognosis and increased survival. Therefore, the study of different patterns and degree of infiltration would help us to better understand the relationship between immune and tumor cells and its prognostic implications.

Methods

This retrospective study includes samples from 57 patients with high grade serous ovarian cancer (HGSOC) who underwent cytoreductive surgery. The pattern of infiltration, localization and degree of lymphocyte infiltration in the tumor was evaluated. A set of clinical variables such as smoking, age, type of surgery, intention of treatment, type of response, as well as lymphocytic infiltration were evaluated to assess prognosis.

Results

In our cohort, the median age was 61.5 years, there were 60% of smokers, and most of the cases were FIGO stages III and IV (15.3%, stage I, 8.5% stage II, 54.3% stage III and 22% stage IV). As expected, patients over 65 years, as well as the group of more advanced stages (III and IV) showed a shorter overall survival (OS, 30.17 vs 99.90 months, p = 0.009; 38.73 months vs NR, p = 0.005, respectively). Smoking status was also analyzed but no significant effect on survival was found (OS, p = 0.935). Interestingly, patients with an intratumoral lymphocyte infiltrate had better prognosis compared to the group that had only a peritumoral pattern (OS, 44.57 months vs NR, p = 0.041). In addition, those with a diffuse infiltration pattern presented a better prognosis compared to those with a focal pattern (OS, 20.20 months vs NR p = 0.003). Finally, a tendency for a better OS was seen for those patients with a strong degree of infiltration in the tumor.

Conclusions

HGSOC represents a group of highly immunoreactive tumors. Those with the best prognosis are represented by an intratumoral, diffuse pattern with a strong degree of infiltration, these findings could open a new window for therapeutic approaches in HGSOC.

Clinical trial identification

Legal entity responsible for the study

Fundación de Investigación Hospital General de Valenecia

Funding

None

Disclosure

All authors have declared no conflicts of interest.