632P - Thromboembolic complications in patients with oesophagogastric adenocarcinoma undergoing preoperative chemotherapy

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Oesophageal Cancer
Complications of Treatment
Gastric Cancer
Gastrointestinal Cancers
Palliative and Supportive Care
Presenter Theodora Germetaki
Citation Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369
Authors T. Germetaki1, K. Kamposioras2, G. Papaxoinis1, J. Weaver1, S. Galloway3, S. Stamatopoulou1, M. Nasralla1, Z. Kordatou1, A. Anthoney4, W. Mansoor1
  • 1Medical Oncology, The Christie NHS Foundation Trust, M20 4BX - Manchester/GB
  • 2Medical Oncology, The Mid Yorkshire Hospitals NHS Trust-Pinderfields General Hospital, WF1 4DG - Wakefield/GB
  • 3Oesophago-gastric Surgery, University Hospital of South Manchester, M23 9LT - Manchester/GB
  • 4Medical Oncology, The Leeds Teaching Hospitals NHS Trust, LS9 7TF - Leeds/GB

Abstract

Background

The scope of the present study was: to describe the incidence of thromboembolic events (TE) in patients (pts) with resectable oesophagogastric (OG) adenocarcinoma receiving preoperative chemotherapy (CT) with curative intent; to assess risk factors of developing TE; to determine their impact on patient outcome.

Methods

Data from 590 pts with OG adenocarcinoma, who received epirubicin, cisplatin and capecitabine (ECX) or 5-fluorouracil (ECF) preoperatively in 3 UK hospitals, between 2009 & 2016, were collected retrospectively.

Results

Median age was 66 years (range 28-85), 81% were males, 21% had gastric primaries, 98% received ECX chemotherapy, and 87% completed all 3 cycles of preoperative CT. In total, 52 pts (9%) had a venous and 22 (4%) an arterial event. Of patients with venous TE, 39 had pulmonary embolism and 13 deep vein thrombosis. Of patients with arterial TE, 7 developed cardiac infarct, 8 limb ischemia, 4 cerebrovascular accident and 3 superior mesenteric artery thrombosis. Arterial TE was associated with much higher inoperability rate compared to cases with venous TE or without TE (77% vs. 31% vs. 20% respectively, p 

Conclusions

Preoperative ECX/ECF chemotherapy for patients with resectable OG adenocarcinoma was associated with relatively high incidence of TE. However, only arterial TE affected patient outcome

Clinical trial identification

Legal entity responsible for the study

Wasat Mansoor

Funding

None

Disclosure

All authors have declared no conflicts of interest.