458P - The Preoperative Blood Lymphocyte-to-monocyte Ratio Acts as a Superior Prognostic Factor and Predicts Tumor Metastasis in Gastric Neuroendocrine Ne...

Date 10 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Neuroendocrine Cancers
Endocrine Cancers
Surgery and/or Radiotherapy of Cancer
Presenter Long-Long Cao
Citation Annals of Oncology (2017) 28 (suppl_5): v142-v157. 10.1093/annonc/mdx368
Authors L. Cao, H. Chang-Ming, J. Lin, J. Lu, C. Zheng
  • Department Of Gastric Surgery, Fujian Medical University Union Hospital, 350001 - Fuzhou/CN

Abstract

Background

The aim of this study is to investigate the prognostic significance of the preoperative blood lymphocyte-to-monocyte ratio (LMR) in gastric neuroendocrine neoplasms (g-NENs).

Methods

We enrolled 177 patients who had been diagnosed with g-NENs and undergone radical surgery. Receiver operating characteristic curve analysis was used to identify the optimal value for the LMR. Univariate and multivariate survival analyses were used to identify prognostic factors. A nomogram was adopted to predict recurrence free survival (RFS) and overall survival (OS) after surgery.

Results

The LMR was significantly lower in patients with g-NENs than in matched normal volunteers (NVs) (P 

Conclusions

As an independent prognostic factor for survivals in patients with g-NENs, the LMR combined with the lymph node ratio and histological type had a more superior ability to predict clinical outcomes in post-surgery patients than the traditional TNM staging system. Patients with low LMRs require close surveillance to identify tumor recurrence early.

Clinical trial identification

Legal entity responsible for the study

Changming Huang

Funding

None

Disclosure

All authors have declared no conflicts of interest.