974P - Reproductive function in patients (pts) with malignant ovarian germ cell tumors (MOGCT) following chemotherapy (ChT)

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Ovarian Cancer
Cancer in Young Adults
Presenter Dzhennet Chekini
Citation Annals of Oncology (2017) 28 (suppl_5): v330-v354. 10.1093/annonc/mdx372
Authors D. Chekini1, A. Tryakin1, M. Fedyanin1, I. Pokataev1, A. Bulanov1, T. Zakharova2, K. Zhordania3, O. Sekhina1, S. Tjulandin1
  • 1Clinical Pharmacology And Chemotherapy Department, N. N. Blokhin Russian Cancer Research Center, 115478 - Moscow/RU
  • 2Pathology, Russian Oncology Research Center named after Blokhin N.N., 115478 - Moscow/RU
  • 3Gynecology Department, N. N. Blokhin Russian Cancer Research Center, 115478 - Moscow/RU

Abstract

Background

MOGCT generally affect young women, grow rapidly, usually involve one ovary and are highly chemosensitive. Only a few studies have evaluated the reproductive outcomes of pts following ChT. The aim of this study was analysis of long-term effects of ChT on reproductive function in a large population of young women treated for MOGCT in our center.

Methods

Inclusion criteria in our study were MOGCT, fertility-sparing surgery, cisplatin- and etoposide-based induction ChT (BEP/EP regimen), age under 40, no relapse following ChT at least 1 year. Blood tests were taken for hormones of ovarian function (follicle-stimulating hormone, luteinizing hormone, estradiol, anti-Müllerian hormone (AMH), inhibin B) to assess their menstrual, reproductive function, post therapeutic status of pregnancy or delivery.

Results

A total of 47/163 (28.8%) pts with MOGCT treated in our center between 1987-2015 satisfied to the criteria. Mean age was 21 years (range, 14-35). Median number of ChT cycles was 4 (range, 1-6). The 5-year OS was 85% for all pts and 100% for these 47 women. All pts recovered their menstrual function during the first year after completion of ChT. With median f.-up 90 mo. (range, 12-228), 23/47 (49%) pts attempted conception, 18/23 (78.3%) women conceived with 20 live birth deliveries. There were 2/18 (11%) miscarriages and 6/18 (33.3%) terminations. Four women were pregnant at the moment of the analysis. Inhibin B level was normal in all 15 evaluated pts (median 74,4 pg/ml, range 10-120). Median of AMH level was 0,97 ng/ml (range 0.08-6). In 10 (52.6%) of 19 pts AMH level was

Conclusions

Unilateral adnexectomy followed by modern cisplatin-based chemotherapy does not adversely affect young women’s fertility and provides high chance for cure.

Clinical trial identification

Legal entity responsible for the study

Russian Cancer Research Center

Funding

None

Disclosure

All authors have declared no conflicts of interest.