1280P - Regulatory variants in cancer-related pathway genes predict survival of patients with surgically resected non-small cell lung cancer

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Cancer in Adolescents
Non-Small-Cell Lung Cancer, Early Stage
Lung and other Thoracic Tumours
Translational Research
Presenter Mi Jeong Hong
Citation Annals of Oncology (2017) 28 (suppl_5): v453-v456. 10.1093/annonc/mdx381
Authors M.J. Hong1, K.M. Shin2, S.Y. Lee3, J.H. Lee4, J.Y. Park3
  • 1Cell And Matrix Research Institute, Kyungpook National University School of Medicine, 700422 - Daegu/KR
  • 2Department Of Radiology, Kyungpook National University, Daegu/KR
  • 3Departments Of Internal Medicine, Kyungpook National University, Daegu/KR
  • 4Biochemistry And Cell Biology, Kyungpook National University School of Medicine, 700422 - Daegu/KR

Abstract

Background

We conducted this study to identify genetic variants in cancer-related pathway genes which can predict prognosis of NSCLC patients after surgery, using a comprehensive list of regulatory single nucleotide polymorphisms (SNPs) prioritized by RegulomeDB.

Methods

A total of 509 potentially functional SNPs in cancer-related pathway genes selected from RegulomeDB were evaluated. These SNPs were analyzed in a discovery set (n = 354), and a replication study was performed in an independent set (n = 772). The association of the SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed.

Results

In the discovery set, 76 SNPs were significantly associated with OS or DFS. Among the 76 SNPs, the association was consistently observed for 5 SNPs (ERCC1 rs2298881C>A, BRCA2 rs3092989G>A, NELFE rs440454C>T, PPP2R4 rs2541164G>A, and LTBP4 rs3786527G>A) in the validation set. In combined analysis, ERCC1 rs2298881C>A, BRCA2 rs3092989, NELFE rs440454C>T, and PPP2R4 rs2541164G>A were significantly associated with OS and DFS (adjusted HR aHR for OS = 1.46, 0.62, 078, and 0.76, respectively; P = 0.003, 0.002, 0.007, and 0.003 respectively; and aHR for DFS = 1.27, 0.69, 0.86, and 0.82, respectively; P = 0.02, 0.002, 0.03, and 0.008, respectively). The LTBP4 rs3786527G>A was significantly associated with better OS (aHR = 0.75; P = 0.003).

Conclusions

Our results suggest that five SNPs in the cancer-related pathway genes may be useful for the prediction of the prognosis in patients with surgically resected NSCLC.

Clinical trial identification

Legal entity responsible for the study

Jae Yong Park

Funding

None

Disclosure

All authors have declared no conflicts of interest.