1477PD - Prognosis of desmoid tumours initially managed with surveillance only at all anatomical locations

Date 11 September 2017
Event ESMO 2017 Congress
Session Sarcoma
Topics Cancer in Adolescents
Soft Tissue Sarcomas
Sarcoma
Presenter Winan van Houdt
Citation Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387
Authors W.J. van Houdt1, A.K. Patel1, R.L. Jones2, M.J. Smith1, A. Miah3, C. Benson2, S. Zaidi3, C. Messiou4, E. Moskovic4, D.C. Strauss1, A.J. Hayes1, O. Husson2, W.T.A. van der Graaf2
  • 1Surgical Oncology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB
  • 2Medical Oncology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB
  • 3Clinical Oncology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB
  • 4Radiology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB

Abstract

Background

Desmoid tumours are locally aggressive mesenchymal tumours that lack metastatic potential. Tumour behaviour is unpredictable and varies along a spectrum from remission to growth. Recently, active surveillance has been increasingly adopted as initial management. The aim of this study is to analyse the need and indications for treatment in desmoid patients initially managed with surveillance only.

Methods

Patients with a desmoid tumour at any anatomical location diagnosed between 1998 and 2016 were selected from a prospectively maintained database. Differences between patient groups were analysed with independent t-tests or Chi-square tests. Inverse univariate cox proportional hazard regression analyses were conducted to assess factors associated with start of treatment, tumour behaviour and pain.

Results

A total of 168 patients initially managed with surveillance only were identified. The tumours were located in an extremity (51), in the abdominal wall (61), intra-abdominally (15), in the chest wall (30) or at other locations (11). From these patients, 33% (n = 55) developed progressive disease, 38% (n = 64) had stable disease and 28% (n = 47) had a remission. Tumours in patients 5 cm were more likely to undergo treatment (p 

Conclusions

Patients with desmoid tumours can be managed with surveillance only, but a large minority still needs treatment after an initial period of surveillance. Pain and tumour growth are the most common indications to start treatment after initial surveillance.

Clinical trial identification

Legal entity responsible for the study

Winette van der Graaf

Funding

None

Disclosure

All authors have declared no conflicts of interest.