295P - Pneumocystis jiroveci pneumonia (PCP) in patients receiving weekly chemotherapy for metastatic breast cancer

Date 11 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Complications of Treatment
Breast Cancer, Metastatic
Breast Cancer
Presenter Silvana Wijaya
Citation Annals of Oncology (2017) 28 (suppl_5): v74-v108. 10.1093/annonc/mdx365
Authors S.T. Wijaya, E. Harrison, M. Moody, C. Wilson, L. Hughes-Davies, C. Caldas, H. Earl, R. Baird
  • Cambridge Breast Unit, Addenbrooke's Hospital, Cb2 0QQ - Cambridge/GB

Abstract

Background

Pneumocystis jiroveci pneumonia (PCP) is thought to be a rare phenomenon in the solid tumour population, particularly in patients with breast cancer. However, it may be increasing within this population as the type and intensity of chemotherapy used changes. There is currently a lack of consensus on PCP prophylaxis in patients who are immunocompromised due to chemotherapy.

Methods

The EPIC electronic health record system was searched for metastatic breast cancer (MBC) patients treated with a weekly chemotherapy (epirubicin/paclitaxel) regimen from October 2014 – February 2016 at Addenbrooke’s hospital (n = 49). A subset of patients diagnosed with PCP (n = 5) was identified. A retrospective analysis was performed on the charts of all patients.

Results

Patients received a mean of 21 weeks (SD = 15, min=1, max=62) of chemotherapy. An overall of 16% (n = 8) of patients had profound lymphopaenia (absolute lymphocyte count

Conclusions

A high incidence of PCP was observed in MBC patients receiving weekly epirubicin/paclitaxel treatment. Additional investigation is needed to define the population of patients at the greatest risk of PCP infection, and to identify those who might benefit from antibiotic prophylaxis.

Clinical trial identification

Legal entity responsible for the study

Cambridge Cancer Centre

Funding

None

Disclosure

All authors have declared no conflicts of interest.