1557P - Nutritional risk as a predictor of short-term outcomes in a prospective cohort of elderly patients with cancer

Date 10 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Supportive Care
Geriatric Oncology
Palliative and Supportive Care
Presenter leticia Sales
Citation Annals of Oncology (2017) 28 (suppl_5): v543-v567. 10.1093/annonc/mdx388
Authors L.T. Sales1, J.T. Oliveira Lima1, A. Bergmann2, M.J.G. Mello1, M. Rebello1, Z. Cavalcanti1, D. Sales1, N. Cruz1, L.C.S. Thuler2
  • 1Oncogeriatry, Hospital IMIP, 50070-550 - Recife/BR
  • 2Phd Program, INCA -NATIONAL CANCER INSTITUTE, 20231-050 - RIO DE JANEIRO/BR

Abstract

Background

To determine if the nutritional risk identified by the Mini NutritionalAssessment Short-Form (MNA®-SF) is an independent predictor of short-term outcomes (infection, hospitalization and premature death).

Methods

prospective cohort study of elderly patients (≥60 years) with a recent diagnosis of cancer admitted to an outpatient oncology unit was performed. Sociodemographic and clinical variables and MNA®-SFwere collected at baseline. The outcomes were healthcare-associated infection, hospitalization and death. Data were analysed using the multivariateCoxproportional hazards models. Overall survival was estimated using the Kaplan–Meier method and survival curves were compared using theLog rank test.

Results

he cohort consisted of 608 elderly patients followed for 180 days. The mean age was 71.9 years (range: 60–96) and 50.2% participants were at risk of malnutrition as measured by the MNA®-SF. During follow-up, 35.5% of participants were hospitalized, 29.4% had healthcare-associated infections and 16.4% died. After adjustment for age, site and stage of cancer, the multivariate regression Cox model showed that being undernourished was an independentpredictor of infection (adjusted Hazard Ratio [aHR]=1.88, 95%CI 1.32–2.67, p 

Conclusions

Nutritional risk at admission was identified as a significant predictor of risk forpremature death, infection, and need for hospitalization in elderly cancer patients. The use of MNA®-SF should be incorporated into regular geriatric assessment of olderpatients with cancer.

Clinical trial identification

NO APPLICABLE

Legal entity responsible for the study

Jurema Telles De Oliveira Lima

Funding

FACEPE CNPQ

Disclosure

All authors have declared no conflicts of interest.