199P - Neutrophil-to-lymphocyte and lymphocyte-to-monocyte ratios in breast cancer

Date 11 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Breast Cancer
Presenter Lorenzo Gerratana
Citation Annals of Oncology (2017) 28 (suppl_5): v43-v67. 10.1093/annonc/mdx362
Authors L. Gerratana1, D. Basile1, S. Zago2, M.G. Vitale1, G. Pelizzari1, M. Bonotto1, C. Bozza1, M. Bartoletti1, V. Fanotto1, C. Lisanti1, M. Cinausero1, S. Barban1, M. Lera1, I. Venuti1, M. Mansutti3, A.M. Minisini3, G. Fasola3, F. Curcio2
  • 1School Of Medical Oncology, Department Of Medicine, University of Udine, 33100 - Udine/IT
  • 2Clinical Pathology Institute, University Hospital of Udine, 33100 - Udine/IT
  • 3Department Of Oncology, University Hospital of Udine, 33100 - Udine/IT

Abstract

Background

Immunity plays a pivotal role in cancer progression and prognosis. A high neutrophil-to-lymphocite ratio (NLR) or a low lymphocyte-to-monocyte ratio (LMR) are respectively associated with systemic inflammation and immune suppression and have been associated with a poor outcome. Aim of this study is to further investigate the interaction between the immune system and breast cancer (BC) through the NLR and LMR.

Methods

This retrospective study analyzed a consecutive cohort of 657 patients (pts) with a diagnosis of pT1 BC, without restrictions regarding lymph node status (T1BC), or metastatic BC (MBC) treated between 2004 and 2017 at the Department of Oncology of Udine (Italy). Differences in terms of NLR and LMR among the two cohorts and between clinico-pathological characteristics in the T1BC subgroup were explored through the Kruskal-Wallis test. The prognostic impact in terms of OS in the T1BC population was investigated through uni- and multivariate Cox regression.

Results

Both NLR and LMR were significantly different between the T1BC and the MBC cohorts. In particular, pts with T1BC had a higher median LMR (3.9 vs 2.9; P = 0.0001) and lower NLR (2 vs 2.7; P = 0.0001). After stratification according to molecular profile, T1BC and MBC cohorts of Luminal B-like subtype were significantly different in terms of both LMR (4.2 vs 3; P = 0.0001) and NLR (2 vs 2.5; P = 0.0001). In triple negative subtype, the difference between TB1C and MBC was observed for NLR (1.9 vs 3.2; P = 0.0272) only. On the other hand, no differences between TB1C and MBC were highlighted for the other subtypes. When focusing on the clinico-pathological characteristics of the T1BC cohort, LMR was associated with progesterone receptor (PR) expression (P = 0.0261) and marginally with the estrogen receptor (ER) expression, while NLR with tumor diameter (P = 0.0240) and marginally with grading. Furthermore, among T1BC pts, NLR had no prognostic impact in terms of OS, while LMR was associated with a better outcome also when corrected for ER, PR and HER2 status (HR 0.44, 95%CI 0.28 - 0.71, P = 0.001).

Conclusions

These results suggest a role for systemic inflammation and immune-suppression in breast cancer, especially in the triple negative and luminal B-like subtypes.

Clinical trial identification

Legal entity responsible for the study

University of Udine

Funding

None

Disclosure

All authors have declared no conflicts of interest.