65P - Influence of emotiogenic brain structures on tumor growth in the experiment

Date 11 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Basic Science
Presenter Elena Korobeynikova
Citation Annals of Oncology (2017) 28 (suppl_5): v1-v21. 10.1093/annonc/mdx361
Authors E. Korobeynikova1, E. Rostorguev2, N.S. Kuznetsova3
  • 1Laboratory Center, Rostov Research Institute of Oncology, 344037 - Rostov-on-Don/RU
  • 2Neirooncological Deparment, Rostov Research Institute of Oncology, 344037 - Rostov-on-Don/RU
  • 3Neurooncological Department, Rostov Research Institute of Oncology, 344037 - Rostov-on-Don/RU

Abstract

Background

Stress is the pathogenetic basis of many diseases. It leads to decreasing resistance of the organism, including antitumor one. Emotional stress of a cancer patient affects the quality of life and treatment outcomes by decreasing the antitumor resistance. Therefore, correction of emotional state is an urgent task. The purpose of the study was to reveal the influence of stimulation of emotiogenic brain structures on the antitumor resistance of animals with cancer.

Methods

Transplantable solid sarcoma S45 in white outbred male rats weighing 230-250 g was used as a model of tumor growth. Implantation of bipolar stimulating electrodes in the subcortical structures of the brain was performed aseptically by stereotactic coordinates. Electrodes were implanted to nucleus lateralis septi (LS) – “positive emotiogenic structure” and to Globus pallium (GP) – “negative emotiogenic structure”; the data were compared to the values in animals without electrodes (controls). The stimulation was performed daily for 2 months without changing the stimulation current.

Results

Stimulation of emotiogenic brain structures influenced the dynamics of S45 growth, and LS stimulation caused the greatest inhibition of tumor growth.Table:

65P

StructureLSGPControls
n91010
Initial tumor V (cm3)3.0±0.53.1±1.92.2±1.2
Final tumor V (cm3)4.7±1.17.5±2.26.8±1.6
Tumor increase (%)53.3±2.8186±6.5211±6.8
Effectiveness index1.40.9
Inhibition of tumor growth (%)30.810.2

Morphological study of the thymus, spleen and lymph nodes of animals with LS showed signs of high functional activity of the organs providing a high level of resistance.

Conclusions

Electrostimulation of LS influences antitumor resistance, significantly improving it. This suggests the expediency of combining specific anticancer drugs and nonspecific effects of psychotropic drugs - anxiolytics in complex treatment of cancer.

Clinical trial identification

Legal entity responsible for the study

Rostov Research Institute of Oncology

Funding

None

Disclosure

All authors have declared no conflicts of interest.