1518P - Gastrointestinal stromal tumors secrete Ghrelin and express ghrelin receptors

Date 11 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics GIST
Presenter changzhen zhu
Citation Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387
Authors C. zhu
  • Department Of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 100730 - Beijing/CN

Abstract

Background

Gastrointestinal stromal tumor (GIST) mainly occurs in the fundus ventriculi. Ghrelin is a multifunctional protein polypeptide, which can promote the occurrence and development of tumor. It is mainly produced in the fundus ventriculi. But the misdiagnosis rate and postoperative recurrence rate is high. This study was to determine the serum ghrelin level in the normal population, patients with GIST before and after operation. And The expression of ghrelin and its receptor was determined in GIST tissue and The expression of ghrelin in adjacent normal tissue in the same patient. We hope that ghrelin can provide a new idea for the diagnosis and prognosis of GIST.

Methods

Preoperative and postoperative serum of 78 patients with GIST and 69 normal persons was collected and determined the level of serum ghrelin by ELISA. Expression of ghrelin and ghrelin receptors in GIST tissue (47 cases) was determined and Expression of ghrelin in adjacent normal tissue was determined at same time by immunohistochemical. We observed whether there were statistically significant differences in statistical analysis.

Results

the average ghrelin in the serum of normal people was 20.14 pg/ml, and 31.25 pg/ml for GIST patients. P = 0.034. The mean value of serum ghrelin in 78 patients with GIST was 31.25 pg/ml before operation and 22.5 pg/ml after operation . P = 0.023. Ghrelin and its receptor expression positive rate was 100% in GIST (47 cases). Among them, Ghrelin: (+) 12%, ( ++) 29%, ( +++) 38%, ( ++ ++) 20% Ghrelin receptors:(+) 4%, ( ++) 23%, ( +++) 27%, ( ++ ++) 46% 4) The expression of ghrelin in tumor tissue was about 2.23 times than that of adjacent normal tissues.

Conclusions

Gastrointestinal stromal tumors secrete Ghrelin and express ghrelin receptors. Ghrelin may serve as an effective indicator for the diagnosis and prognosis of GIST.

Clinical trial identification

This experiment has been examined and approved by the ethics committee.there is no trial protocol number.the release date is oct 2015.

Legal entity responsible for the study

Peking Union Medical College Hospital

Funding

Beijing Municipal Commission of Health and Family Planning

Disclosure

All authors have declared no conflicts of interest.