1502P - Evolution in Neutrophil-to-lymphocyte ratio (NLR) among advanced Soft Tissue Sarcoma (STS) patients treated with pazopanib within EORTC 62043/62072...

Date 11 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Anti-Cancer Agents & Biologic Therapy
Soft Tissue Sarcomas
Sarcoma
Presenter Eleonora De Maio
Citation Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387
Authors E. De Maio1, N. Touati2, S. Litière3, S. Sleijfer4, W.T.A. van der Graaf5, A. Le Cesne6, L. D'Ambrosio7, P.G.G. Casali8, A. Italiano9, I. Desar10, A. Gronchi11
  • 1Eortc, European Organisation for Research and Treatment of Cancer, 1200 - Brussels/BE
  • 2Statistics, EORTC, 1200 - Brussels/BE
  • 3Statistics, EORTC - European Organisation for Research and Treatment of Cancer, 1200 - Brussels/BE
  • 4Medical Oncology, Erasmus MC Cancer Institute, 3075 EA - Rotterdam/NL
  • 5Medical Oncology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB
  • 6Department Of Medical Oncology, Gustave Roussy Cancer Campus, 94805 - Villejuif/FR
  • 7Medical Oncology, IRCCS Istituto di Candiolo, 10060 - Candiolo/IT
  • 8Adult Mesenchymal Tumour And Rare Cancer Medical Oncology Unit, Fondazione IRCCS - Istituto Nazionale dei Tumori, 20133 - Milan/IT
  • 9Medicine, Institute Bergonié, 33076 - Bordeaux/FR
  • 10Medical Oncology, Radboud University Medical Centre Nijmegen, 6500 HB - Nijmegen/NL
  • 11Department Of Surgery, Fondazione IRCCS - Istituto Nazionale dei Tumori, 20133 - Milan/IT

Abstract

Background

A high NLR has been shown to be associated with a poor prognosis in several solid tumors including STS and might be helpful for patient stratification and individual risk assessment. The aims of this study were to confirm that higher NLR at baseline is associated with worse prognosis in STS and to evaluate if an early decline of NLR during treatment with pazopanib is associated with a more favorable prognosis.

Methods

The single-arm phase II EORTC 62043 and placebo-controlled phase III EORTC 62072 were both investigating the effect of pazopanib in patients with advanced STS. We evaluated NLR at baseline and 50 days later. Multivariate analyses on pazopanib-treated patients investigated the prognostic value on both Progression-Free Survival (PFS) and Overall Survival (OS) of NLR at baseline as well as the predictive value of changes in NLR from baseline to the 50-days landmark. Sensitivity analyses were conducted on the placebo-treated patients.

Results

Among the 333 eligible patients treated with pazopanib, a NLR at baseline ≥3 was associated with shorter PFS and OS in comparison to NLR

Conclusions

In this study, limited by its retrospective design, the prognostic value of NLR at baseline was confirmed in advanced STS patients, irrespective of treatment. Changes in NLR during the first 50 days of treatment with pazopanib were not associated with patient outcome and can therefore not be used as an early marker for response.

Clinical trial identification

Legal entity responsible for the study

EORTC

Funding

EORTC STBSG

Disclosure

A. Le Cesne: Pfizer, Lilly, Amgen, Novartis, Pharmamar Honoraria, myself, compensated. P.G. Casali: Consultant/Advisory, Honoraria and Research funds (for the institution) from Amgen, Dompé, Bayer, Blueprint Medicines, Eisai, Eli Lilly, Daiichi Sankyo Pharma, Epizyme Inc., Merck SD, Merck Serono, Nektar Therapeutics, Novartis, Pfizer and PharmaMar. All other authors have declared no conflicts of interest.