1622P - Evaluation of Quality of Life in survivors with malignant pleural mesothelioma in Japan

Date 09 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Mesothelioma
Lung and other Thoracic Tumours
Presenter Isao Oze
Citation Annals of Oncology (2017) 28 (suppl_5): v568-v572. 10.1093/annonc/mdx389
Authors I. Oze1, Y. Nagamatsu2, K. Aoe3, K. Hotta4, K. Kato5, J. Nakagawa6, K. Hara6, T. Kishimoto7, N. Fujimoto8
  • 1Division Of Molecular And Clinical Epidemiology, Aichi Cancer Center Research Institute, 464-8681 - Nagoya/JP
  • 2College Of Nursing, St. Luke’s International University, Tokyo/JP
  • 3Department Of Medical Oncology, National Hospital Organization Yamaguchi-Ube Medical Center, Ube/JP
  • 4Center For Innovative Clinical Medicine, Okayama University Hospital, Okayama/JP
  • 5Department Of Radiology, Kawasaki General Medical Center, Okayama/JP
  • 6Department Of Nursing, Okayama Rosai Hospital, Okayama/JP
  • 7Department Of Medicine, Okayama Rosai Hospital, Okayama/JP
  • 8Department Of Medical Oncology, Okayama Rosai Hospital, Okayama/JP

Abstract

Background

Malignant pleural mesothelioma (MPM) is the malignancy with poor prognosis. Most patients with MPM present severe symptoms such as pain, dyspnea and fatigue. Because of the symptoms and poor prognosis, MPM survivors would have poor Quality of Life (QOL), however, their QOL has not been well evaluated.

Methods

Subjects were the survivors of MPM. We asked the cancer hospitals in Japan and MPM Patients' Association to distribute the self-administered questionnaire. QOL was evaluated using scales of the EORTC QLQ-C30 and QoQoLo short version. In addition to the QOL, clinical factors were collected using the questionnaire. Mean and its standard deviation were used to evaluate QOL scores. Wilcoxon rank sum test was used to compare the QOL scores. Factors affecting the QOL score were evaluated by multiple regression model.

Results

In total, 133 survivors with MPM participated in the study. Regarding the QOL evaluated by QLQ-C30: functional scales were poor (scores >50), while symptom scales were not so poor (scores 2 years from diagnosis, and female. Similarly, good PS and >2 years from diagnosis were the factors caused higher total score of CoQoLo core domein.

Conclusions

Survivors with MPM had physical and psychological difficulties. Even the survivors with good PS had functional difficulty. Individualized supports are required for survivors with MPM.

Clinical trial identification

Legal entity responsible for the study

Nobukazu Fujimoto

Funding

Ministry of Health, Labour and Welfare, Japan

Disclosure

All authors have declared no conflicts of interest.