296P - Detection of early cardiac effects of Docetaxel Plus Trastuzumab and Pertuzumab through strain rate imaging in Patients with HER2-Positive Metastat...

Date 11 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Anti-Cancer Agents & Biologic Therapy
Complications of Treatment
Breast Cancer, Metastatic
Breast Cancer
Imaging, Diagnosis and Staging
Presenter Vasiliki Michalaki
Citation Annals of Oncology (2017) 28 (suppl_5): v74-v108. 10.1093/annonc/mdx365
Authors V. Michalaki1, G. Koutroulis1, I. Psychogios1, E. Karvouni2, I. Vasiliou1, C. Papadimitriou1
  • 12nd Department Of Surgery, Areteion Hospital, University of Athens, 11528 - Athens/GR
  • 2Histopathology Department, Areteion Hospital, University of Athens, 11528 - Athens/GR

Abstract

Background

Dual anti- HER2 therapy with trastuzumab and pertuzumab in combination with taxane-based chemotherapy improves overall survival in patients with metastatic HER2-positive breast cancer. There is a critical need to investigate the potential cardiotoxicity of dual anti-HER2 blockade, given the importance of HER2 signaling in cardiac homeostasis and stress response. Sequential left ventricular (LV) ejection fraction (EF) assessment has been mandated to detect myocardial dysfunction. Changes in cardiac function induced by this therapy, however, are subtle and difficult to quantitate by conventional imaging methods. Doppler myocardial imaging-based velocity, strain, and strain rate measurements have been shown to sensitively quantify abnormalities in cardiac function in other settings. The aim of this study was to determine if sensitive indices of left ventricular (LV) dysfunction, specifically strain rate imaging, would be useful for addressing the early detection of dual anti-HER2 mediated cardiotoxicity.

Methods

Patients with 0-1 lines of prior therapy were treated with 8 cycles of docetaxel (75mg/m(2) plus trastuzumab (8 mg/kg loading dose followed by 6 mg/kg) and pertuzumab (840 mg loading dose followed by 420 mg every 3 weeks. Conventional and Doppler myocardial imaging echocardiography were obtained at baseline and every 2 cycles of treatment. Segmental peak systolic longitudinal and radial velocity, strain, and strain rate (SR) were measured.

Results

Twenty-seven women (median age 52.2 years) were enrolled in the study. There was no overall change in Left ventricular dimensions, ejection fraction, and systolic myocardial velocity. In contrast, a significant reduction in longitudinal and radial strain and strain rate was found after 8 cycles (longitudinal strain -12.8% +/- 2.2% vs baseline (P = .001); radial strain 29.3% +/- 7.1% vs 50.3% +/- 10.6%, P < .001 vs baseline). Changes in radial function appeared earlier and were more pronounced than in longitudinal direction.

Conclusions

In contrast with conventional echocardiography myocardial velocity measurements allowed detecting subtle changes in longitudinal and radial left ventricular function after 8 cycles of therapy. We suggest that strain rate imaging identifies preclinical myocardial dysfunction earlier than conventional measures in women undergoing treatment with dual anti-HER2 therapy for metastatic breast cancer and could be used for cardiac function monitoring.

Clinical trial identification

Legal entity responsible for the study

Vasiliki Michalaki

Funding

None

Disclosure

All authors have declared no conflicts of interest.