1403P - Community-based Lung Cancer Screening of High-risk Population with Low-dose Computed Tomography in China

Date 10 September 2017
Event ESMO 2017 Congress
Session Poster display session
Topics Cancer in Adolescents
Cancer Aetiology, Epidemiology, Prevention
Lung and other Thoracic Tumours
Presenter Fangfei Qian
Citation Annals of Oncology (2017) 28 (suppl_5): v502-v506. 10.1093/annonc/mdx383
Authors F. Qian1, W. Yang1, H. Wang1, J. Teng1, Y. Zhang1, Q. Chen2, J. Ye2, J. Lou1, R. Shi3, L. Jiang1, A. Gu1, Y. Zhao1, B. Jin1, X. Zhang1, J. Xu1, Y. Lou1, B. Han1
  • 1Department Of Pulmonary Medicine, Shanghai Chest Hospital, 200030 - Shanghai/CN
  • 2Department Of Radiology, Shanghai Chest Hospital, 200030 - Shanghai/CN
  • 3Department Of Preventive Medicine, Shanghai Jiaotong University, 200030 - Shanghai/CN

Abstract

Background

Low-dose computed tomography (LDCT) screening for lung cancer has been recommended for high-risk individuals meeting the National Lung Screening Trial (NLST) criteria. However, there still is a debate concerning respective recommendations for Asian countries. Meanwhile, the proper duration and interval for lung cancer screening remains uncertain.

Methods

From November 2013 to July 2016, participants from Xuhui district of Shanghai were aged 45-70 years, and with either of the following risk factors: 1) smoking history ≥20 pack-years, and, if a former smoker, had quit within the past 15 years; 2) cancer history in immediate family members; 3) personal cancer history; 4) professional exposure to carcinogens; 5) long term exposure to second-hand smoke; 6) long term exposure to cooking oil fumes. The eligible participants were randomly assigned to a screening arm with two rounds of alternate years LDCT screens and a control arm.

Results

A total of 6659 eligible participants were enrolled, 3147 participants were randomly assigned to control arm, 3512 were assigned to LDCT prevalence screening (S1), of which 1516 participants underwent the second round of LDCT screening (S2) in the alternate year. Positive screening results were observed in 849(24.2%) participants in S1 and 380 (28.0%) in S2. 80 (2.3%) cases were highly suspected of lung cancer in S1 and 31 (2.0%) in S2 according to the suggestions from multiple disciplinary team. By April 2017, lung cancer was diagnosed in 44 participants (1.3%) after S1, 12 (0.8%) after S2, and 10 (0.3%) in the control group (stage 0 to I: 97.7%, 91.7% vs 20%; stage II to IV: 2.3%, 8.3% vs 80%). Only 18 (32%) of these 56 lung cancer patients detected by LDCT would have qualified as NLST high-risk patients. There were 2 lung cancer-specific deaths in control group, whereas 0 in the screening arm participants.

Conclusions

LDCT screening increased the detection of early-stage lung cancer and reduced lung cancer-specific mortality. In China, lung cancer CT screening may also benefit patients outside the NLST criteria with great efficiency. Screening done at biennial intervals could be taken into consideration due to few advanced-stage diseases.

Clinical trial identification

Legal entity responsible for the study

Shanghai Chest Hospital

Funding

Shanghai Municipal Commission of Health and Family Planning

Disclosure

All authors have declared no conflicts of interest.