1159P - The association between survival and maximum standardized uptake value of liver metastases detected by 18-fluoro-2-deoxy-D-glucose positron emissio...

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Carcinoma of Unknown Primary Site
Imaging, Diagnosis and Staging
Presenter Efnan Algin
Citation Annals of Oncology (2014) 25 (suppl_4): iv394-iv405. 10.1093/annonc/mdu345
Authors E. Algin1, A. Ozet2, O. Gumusay2, B. Cetin3, U.O. Akdemir4, M. Benekli5, U. Coskun2, A. Üner2, O. Kapucu4, S. Buyukberber2
  • 1Medical Oncology, Ankara Numune Education and Research Hospital, 06100 - Ankara/TR
  • 2Medical Oncology, Gazi University Faculty of Medicine, Ankara/TR
  • 3Medical Oncology, Van Education and Research Hospital, Van/TR
  • 4Nuclear Medicine, Gazi University Faculty of Medicine, Ankara/TR
  • 5Medical Oncology, Gazi University Faculty of Medicine, 06500 - Ankara/TR

Abstract

Aim

The objective of this retrospective study was to investigate the association between survival and maximum standardized uptake values (SUVmax) of liver metastases detected by pre-treatment positron emission tomography-computed tomography (PET-CT) in patients with adenocarcinoma of unknown primary origin (ACUP).

Methods

A total of 58 patients with ACUP and liver metastases confirmed histopathologically by liver biopsy and pre-treatment PET-CT were included in this study. SUVmax values of the liver lesions were measured and their association with survival was investigated.

Results

The median age was 62; 63.8% of the patients were male and 36.2% were female. The median overall survival (OS) was calculated as 10.7 months. The median SUVmax of the liver metastases was 8.6. Accordingly, two groups were established: those with a value <8.6 and those with ≥8.6. There was no difference between the two groups with respect to general characteristics. Median OS was 13.2 months in the group with SUVmax <8.6 compared with 7.4 months in the group with SUVmax ≥8.6. This difference was statistically significant (p = 0.033). SUVmax (HR 1.104, 95% CI 1.013-1.204, p = 0.025), age (HR 1.033, 95% CI 1.002-1.064, p = 0.034), presence of chemotherapy (HR 2.296, 95% CI 1.136-4.641, p = 0.021) and LDH level (HR 1.002, 95% CI 1.001-1.003, p = 0.007) were specified as the independent prognostic factors affecting the survival in the multivariable analysis. This is the first report evaluating the impact of SUVmax for liver metastases on ACUP patient survival.

Conclusions

The SUVmax of liver metastases evaluated by PET-CT has an impact on survival in patients with ACUP.

Disclosure

All authors have declared no conflicts of interest.