684P - Results of treatment of locally advanced gastric cancer in the elderly patients

Date 30 September 2012
Event ESMO Congress 2012
Session Poster presentation II
Topics Gastric Cancer
Geriatric Oncology
Presenter Dilshod Egamberdiev
Authors D. Egamberdiev1, M. Djuraev2, S. Khudayorov3, O. Nematov3, A. Babaev3, H. Tuyev3
  • 1Dpt. International Relations, National Cancer Center of Uzbekistan, 100174 - Tashkent/UZ
  • 2National Cancer Center of Uzbekistan, 100174 - Tashkent/UZ
  • 3Abdominal Oncology, National Cancer Center of Uzbekistan, 100174 - Tashkent/UZ

Abstract

Background

Although the incidence of gastric cancer has declined in the general population, it is the second most frequent cancer in Uzbekistan with its incidence in the elderly increasing as a result of increased life expectancy. This present study tried to determine the role of age on outcomes of surgical treatment for gastric cancer in Uzbek population.

Methods

The study reviewed 288 patients who underwent gasterectomy for locally advanced gastric cancer. The clinicopathological features of elderly patients (≥75 years, n = 167) and younger patients (<70 years, n = 121) were compared. Stage III is established in 164 (56.9%) patients, stage IV in 124 (43.1%). Radical curative surgery was performed in 163 (56.6%) patients, palliative resection in 125 (43.4 %). From them gastrectomy was performed in 128 (44.8%) patients, proximal subtotal resection in 24 (8.3%) and distal subtotal resection in 136 (47.2%). Combined operations were performed in 87 (30.2 %) patients.

Results

Distinct characteristics of elderly patients included more frequent underlying disease, deeper invasion, and more frequent lymph node metastasis. The postoperative morbidity and mortality rate did not differ between the two groups. Age, preoperative performance status, preoperative transfusion, and presence of comorbidity were not independent predictors of postoperative complications. However, the extent of gastric resection and combined resection were closely related to postoperative complications in patients with non-curative gastrectomy.

Conclusion

Analysis the direct results of surgical treatment of elderly gastric cancer patients shows that, age is not a limiting factor for performing curative surgery. However, the risk of postoperative morbidity should be considered carefully in total gastrectomy and combined resection.

Disclosure

All authors have declared no conflicts of interest.