192P - Mesothelin and individual characteristics in a cohort of asbestos exposed workers

Date 30 September 2012
Event ESMO Congress 2012
Session Poster presentation II
Topics Mesothelioma
Translational Research
Presenter Manlio Mencoboni
Authors M. Mencoboni1, L.A. Michelazzi2, A. Cioè2, A. Bruzzone3, L. Delcorso3, V. Mortara4, P. Marroni5, G. Dini2, S. Marcenaro3, F. Spigno2
  • 1Medicina Interna, Ospedale Villa Scassi, 16149 - Genova/IT
  • 2University Of Genoa, Occupational Medicine, 16100 - Genoa/IT
  • 3Oncologia Medica, Ospedale Villa Scassi, 16149 - Genova/IT
  • 4Inail, National Institute for Occupational Medicine (INAIL), 16100 - Genoa/IT
  • 5Laboratory Medicine, National Cancer Institute, 16100 - Genoa/IT

Abstract

Headings

The soluble mesothelin-related peptide (SMRP) is a candidate marker in the diagnosis and prognosis of mesothelioma, as well as in the screening of subjects with asbestos exposure. SMRP seems to be influenced by some individual characteristics and clinical factors.

Objective

The objective of this study was to evaluate the association between serum SMRP and some individual characteristics in 1704 subjects exposed to asbestos for working reasons.

Design and methods

Participants underwent clinical examination and were interviewed on medical history, occupational exposure, smoking and weight. SMRP was measured by a ELISA assay.

Results

Median SMRP was 0.45 (IQR 0.30-0.67) nmol/l. SMRP was correlated with age (p < 0.001) and was higher in current smokers than in former-smokers or never-smokers (p < 0.001). An inverse association was found between the marker and BMI (p < 0.001). Overall, SMRP concentration was lower in healthy subjects (N 1217, median 0.43 nmol/l) than in all benign diseases (N 357, median 0.51 nmol/l; p < 0.001) and in tumors (N 118, median 0.52 nmo/l, p = 0.03). Serum SMRP values were higher in non neoplastic subjects in which an asbestos-related pleural lesion (APL) was diagnosed (N 152, median 0.65 nmol/l) with respect tumors (p = 0.003). Median SMRP was 0.61 nmol/l in APL alone and 1.13 nmol/l when the lesions were associated with other benign diseases. Multivariate analysis confirmed the positive association between SMRP and age, smoking and asbestos-related pleural lesions, while SMRP was confirmed to be inversely associated with body mass index.

Conclusions

Data on a large series of subjects with asbestos exposure confirmed that serum SMRP is associated to a number of clinical and demographic variables.

Disclosure

All authors have declared no conflicts of interest.