1081P - Low-dose involved-field radiotherapy in relapsed low-grade non-Hodgkin's lymphoma in elderly patients (Mansoura University experience)

Date 30 September 2012
Event ESMO Congress 2012
Session Poster presentation II
Topics Lymphomas
Geriatric Oncology
Surgery and/or Radiotherapy of Cancer
Presenter Ibrahim Awad
Authors I. Awad, H. Wahba, H. El-Hadaad
  • Clinical Oncology, Mansoura University Hospital School of Medicine, 35511 - Mansoura/EG

Abstract

Purpose

To assess the response rate, duration of response and prognostic factors affecting response after low-dose involved field radiotherapy in patients with relapsed low-grade B-cell non-Hodgkin lymphoma.

Patients and methods

Forty-four patients of relapsed low grade B-cell non-hodgkin lymphoma were included. Patients were treated with, involved field radiotherapy of a total dose of 4 Gy (2 x 2 Gy) using 6-15 Mv photon or electron beam.

Results

Most patients were above age of 60 years (59%) with male predominance. Follicular lymphoma was the most common pathological type, bulky disease (>5 cm) was presented in 61.4%. Patients received only 2 regimens were 63.7% and 31.8% had > 2 involved sites. No treatment related toxicity was observed. The overall response rate was 88.7%; complete response was reached in 59.1% and stable disease in 6.8%, progressive disease in 4.5% .Median time to local progression was 33 months (95% CI 23.70-42.29), 2 –year local progression free survival was 78%. Response rate was found to be dependent on age, number of involved sites and lymph node size but independent on sex, pathological type, number of prior regimens, LDH level and time since diagnosis.

Conclusion

Short-course-low dose palliative radiotherapy (2 x 2 Gy) affords an attractive option for treatment of relapsed low-grade non-Hodgkin's lymphoma due to high response rates. However, these results had to be confirmed in a larger number of patients.

Disclosure

All authors have declared no conflicts of interest.