1396P - KBP-2010-CPHG: characteristics of 6,083 new cases of NSCLC according to sex

Date 30 September 2012
Event ESMO Congress 2012
Session Poster presentation II
Topics Cancer Aetiology, Epidemiology, Prevention
Lung and other Thoracic Tumours
Presenter Didier Debieuvre
Authors D. Debieuvre1, C. Locher2, I. Bourlaud3, M. Zaegel4, M. Le Poulain-Doubliez5, J. Piquet6, T. Collon6, F. Martin7, F. Blanchon2, M. Grivaux2
  • 1Pneumology, General hospital, 68070 - Mulhouse/FR
  • 2Pneumology, General hospital, Meaux/FR
  • 3Pneumology, General hospital, Niort/FR
  • 4Pneumology, General hospital, Le-Coudray-Chartres/FR
  • 5Pneumology, General hospital Manchester, Charleville-Mézières/FR
  • 6Pneumology, General hospital, Montfermeil-Le-Raincy/FR
  • 7Pneumology, General hospital, Compiègne/FR

Abstract

Lung cancer is a major public health problem due to its continued increase. In 2010, the French College of General Hospital Respiratory Physicians (CPHG) performed a prospective multicenter epidemiological study (KBP-2010-CPHG) to describe the baseline characteristics and management of all new cases of primary lung cancer; to evaluate 1, 4 and 5-year patient survival rates; and to compare results with those from a similar study performed 10 years ago (KBP-2000-CPHG). Data were collected on a standardized form for all patients ≥18 years with primary lung cancer, histologically or cytologically diagnosed between January 1 and December 31, 2010 and managed in a general hospital. 7,610 patients were enrolled in 119 centers. 6,083 patients (86.3%) had non-small-cell lung cancer (NSCLC); among them, 24.4% were female (vs. 16% in 2000; p < .0001). There was no difference between male and female NSCLC patients regarding age (65.7± 10.9 vs. 64.9± 13.0, p = 0.03). Regarding smoking status, between 2000 and 2010, women remained more frequently non-smoker compared to men (34.2% vs. 4.7%), less frequently former smoker (21.3% vs. 46.8%) and showed lower consumption (37.2 vs. 43.7 PY) (p < .0001). However, in 2010, the percentage of non-smokers nearly doubled in men (2.5% vs. 4.7%; p < .0001) whereas it remained stable in female (p < .32). Regarding tumor characteristics, between 2000 and 2010, the percentage of adenocarcinomas significantly increased in both women (53.4% in 2000 vs. 65.9% in 2010; p < .0001) and men (32.4% vs. 49.4%; p < .0001). However, in 2010, tumors remained more frequently adenocarcinomas in women than in men (65.9% vs.49.4%; p < .0001). In addition, in 2010, when explored (48.5% in women vs. 31.0% in men; p < .001), an EGFR mutation was more frequently found in women than men (20.6% vs. 5.2%; p < .0001), stage IV tumor was more frequent in women than men (62.4% vs. 56.9%; p = 0.0008), and regarding first-line treatment, 64.5% of women vs. 61.0% of men (p = .01) received chemotherapy and 13.4% of women vs. 5.7% of men (p < .0001) targeted therapy. In 10 years, percentages of women, non-smokers among men, and adenocarcinomas in both men and women increased. However, differences between women and men in baseline and tumor characteristics persist.

Disclosure

All authors have declared no conflicts of interest.